Vasoactive hormones gene polymorphism and myocardial remodeling in chronic glomerulonephritis


E.S. Kamyshova, M.Yu. Shvetsov, I.M. Kutyrina, T.E. Rudenko, V.V. Nosikov

SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation; State Research Centre of Russian Federation “GosNIIGenetics”
Aim. Study of association of АСЕ, CYP11B2 and NOS3 gene polymorphisms with echocardiographic signs of left ventricular (LV) remodeling in patients with chronic glomerulonephritis.
Methods. Echocardiography was performed in 80 patients with chronic glomerulonephritis (38 male, 42 female). Left ventricular hypertrophy/left ventricular diastolic dysfunction were detected. Polymorphysms of the following genes were indentified: I/D of АСЕ gene, С(-344)Т of CYP11B2 gene and 4a/4b of NOS3 gene.
Results. Left ventricular hypertrophy was detected in 21,7 %, left ventricular diasctolic dysfunction in 26,3 %
of patients with chronic glomerulonephritis. Signs of cardiac remodeling were associated with age, body mass index (BMI), blood pressure (BP), smoking, dyslipoproteidemia, hyperphibrinogenemia, glomerular fitration rate and serum phosphate concentration. Polymorphisms of АСЕ, CYP11B2 and NOS3 genes were not associated with left ventricular hypertrophy prevalence. Carriers of Т allele of CYP11B2 gene demonstrated higher values of integral of velocity of left ventricular left filling and lower levels of Е/А index in comparison with CC homozygotes. Carriers of Т allele of CYP11B2 gene also had a trend to increase of end diastolic size of left ventricle. Diastolic dysfunction was more often found in 4b allele homozygous carriers of NOS3 gene.
Conclusion. Polymorphisms of renin-angiotensin-aldosterone system genes and NOS3 gene are not associated with left ventricular hypertrophy in chronic glomerulonephritis. Carriers of 4b/4b allele of NOS3 gene have a trend to left ventricular dysfunction development.

About the Autors


Kamyshova E.S., MD, PhD, senior research officer of nephrology division of SRI of urolephrology and human reproductive health of SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
E-mail: kamyshova-es@yandex.ru
Shvetsov M.Yu., MD, PhD, leading research officer of nephrology division of SRI of urolephrology and human reproductive health of SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
Kutyrina I.M., MD, PhD, professor, leading research officer of nephrology division of SRI of urolephrology and human reproductive health of SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
Rudenko T.E., MD, PhD, senior research officer of nephrology division of SRI of urolephrology and human reproductive health of SBEU HPE First Moscow State Medical University n.a. I.M. Sechenov of Ministry of Healthcare of Russian Federation
Nosikov V.V., BD, PhD, professor, head of molecular genetics and genome dactyloscopy laboratory of State Research Centre of Russian Federation “GosNIIGenetics”


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