Русский
Urine levels of matrix metalloproteinases and their inhibitors as the marker of activity of chronic glomerulonephritis
Li O.A., I.N. Bobkova, MD, PhD, L.V. Kozlovskaya, MD, PhD, Prof
I.M. Sechenov Moscow Medical Academy
MMP-2, MMP-9, TIMP-2, PAI-1, nephroscelrosis, chronic glomerulonephritis,
Urinary excretion matrix metalloproteinase (ММP-2 and ММP-9), tissue inhibitor MMP (ТIМP-2) and inhibitor of plasminogen type 1 activator (PAI-I) was investigated. Patients with chronic glomerulonephritis (CG) (I group (n=23) – CG with proteinuria of subnephrotic range (SNPU), II group (n=26) – CG with nephrotic syndrome (NS), III group (n=22) – CG with advanced proteinuria (PU) and transient renal failure (RF), IV group (n=15) – CG with high PU and permanent RF). With increasing of CG activity (advanced MS, NS appearance, acute nephritic syndrome development) we found relatively balanced increase of MMP, TIMP and PAI-I urine levels. In group of patients with permanent RF decrease of MMP urine excretion and acute increase of PAI-I concentration in the urine were found. The level of MMP and TIMP urine excretion at patients with progressive CG straightly correlated with 24-h PU level and inversely correlated with serum creatinine level. Conclusion: changes in MMP, TIMP and PAI-1 urinary excretion levels can be used as a marker of kidney disease activity and severity in chronic glomerulonephritis.
Urinary excretion matrix metalloproteinase (ММP-2 and ММP-9), tissue inhibitor MMP (ТIМP-2) and inhibitor of plasminogen type 1 activator (PAI-I) was investigated. Patients with chronic glomerulonephritis (CG) (I group (n=23) – CG with proteinuria of subnephrotic range (SNPU), II group (n=26) – CG with nephrotic syndrome (NS), III group (n=22) – CG with advanced proteinuria (PU) and transient renal failure (RF), IV group (n=15) – CG with high PU and permanent RF). With increasing of CG activity (advanced MS, NS appearance, acute nephritic syndrome development) we found relatively balanced increase of MMP, TIMP and PAI-I urine levels. In group of patients with permanent RF decrease of MMP urine excretion and acute increase of PAI-I concentration in the urine were found. The level of MMP and TIMP urine excretion at patients with progressive CG straightly correlated with 24-h PU level and inversely correlated with serum creatinine level. Conclusion: changes in MMP, TIMP and PAI-1 urinary excretion levels can be used as a marker of kidney disease activity and severity in chronic glomerulonephritis.
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