Experimental models are widely used to search mechanisms of kidney disease progression and highly selective target therapeutic strategies. In this review examine basic experimental models, used for glomerulopathy research – nephrotoxic nephritis, anti-Thy 1.1-nephritis, puromycin-amynonucleoside nephrosis, Haimann nephritits; for progressive renal failure: subtotal (5/6) nephrectomy: tubulointerstitial nephritis – are presented.