Clinical sighnificance of determination of interleukin-8 and interleukin-18 in blood serum and urine in patients with nephrotic syndrome


A.A. Lyndin, V.V. Dlin, V.V. Malinovskaya, E.A. Rujitskaya, T.G. Shapovalova, T.S. Guseva, O.V. Parshina, M.B. Boyadjan, M.Yu. Yudin

Aim. Assessment of clinical significance of serum and urinary levels of interleukin -8 (IL-8) and -18 (IL-18) in children with primary glomerulonephritis with nephrotic syndrome. Methods. 55 children age 2 -17 years (42 boys and 13 girls) with nephrotic syndrome (NS) were included into the study: 13 - with debut of glomerulonephritis with NS, 10 - with recurrent NS, 32 - with steroid-dependent NS. All patients were divided into 3 groups according to NS activity; 1st - maximal activity of NS, 2nd- minimal activity of NS, 3rd - with remission of NS for >4 months. 9 healthy children served as control group. Results. No correlation was found between serum levels of IL-8 and IL-18 and activity of NS. In highest activity of NS urinary concentration of IL-8 and IL-18 was significantly higher, than in other groups of children with NS and healthy controls. In patients with NS debut sensitivity to glucocorticosteroids was associated with decrease of urinary levels of IL-8 and IL-18 in 3-4 weeks. Conclusion. Urinary levels of IL-8 and IL-18 can detect activity of glomerulonephritis in children and can be used for prediction of response to glucocorticosteroids.

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