Correlation of hypoxia-inducible factor-1α (HIF-1α) expression in kidney tissue in chronic glomeruloneohritis (GN) with nephrosclerosis severity, deterioration of renal function and anemia was studied. Chronic GN progression was correlated with morphological signs of tubulo-interstitial ischemia. Increased HIF-1α tubular production was associated with lower risk of anemia development at patients with chronic GN and nephrosclerosis. Conclusion. Production of HIF-1α by renal tubular epithelium can be considered as one of the protective mechanisms against anemia development.

Keywords: nephrosclerosis, anemia, hypoxia-induced factor-1α, chronic glomerulonephritis