Purpose. Characterization of daily rhythm of blood pressure in patients with arterial hypertension stages I-II with hyperuricosuria/hyperuricaemia. Materials and methods. 24-hour BP monitoring was performed in 71 patients with arterial hypertension stages I-II not receiving ongoing antihypertensive therapy. In addition to conventional physical examination, all patients were examined for signs of metabolic syndrome, uricemia, and uricosuria. Results. The insufficient nocturnal decrease of BP was detected in 26% of patients with hyperuricosuria/hyperuricaemia, in 23% - increase of BP in the night, and in 13% - excessive reduction BP level at night. The number of hypertensive patients with night-peacker type of diurnal curve was significantly greater in the group with hyperuricemia/hyperuricosuria compared with those who have no violations of uric acid metabolism (23 and 3% respectively, p <0.01). Conclusion. Hyperuricemia/hyperuricosuria in arterial hypertension stages I-II predisposes to disorders of the diurnal curve of blood pressure, which characterized mainly by insufficient decrease or further increase of BP at night.

Keywords: 24-hour blood pressure monitoring, hyperuricosuria, hyperuricaemia, uric acid, arterial hypertension