Association of prehypertension with risk factors of chronic kidney disease, arterial hypertension and atherosclerosis


Burmagina A.G., Nikolaev A.Yu.

Russian Medical Academy of post diploma Education of Russian Federation, Moscow
Aim. Study of prevalence of chronic kidney disease (CKD) in patients with high normal blood pressure (prehypertension) and normanl blood pressure (BP) with assessment of determinants of arterial hypertension and atherosclerosis. Methods. 59 male patients (mean age 43,4±1,2 years) with high normal BP (group 1) and 15 male patients (mean age 35,5±2,5 years) wuth normal BP (group 2). Body mass index (BMI), waist circumference (WC), lipid metabolism parameters, serum C-reactive protein, plasma homocysteine and insulin concentrations, HOMA index, uric acid and microalbuminuria were determined. In all patients estimated glomerular filtration rate (eGFR) and left ventricular mass index (LVMI) were calculated.
Results. High normal BP is associated with risk of CKD, arterial hypertension and atherosclerosis. Patients with high normal BP have higher BMI, WC, lipid metabolism parameters, eGFR, HOMA index, microalbuminuria, LVMI and alterations in 24-hour BP profile.
Conclusion. High normal BP is associated with high risk of CKD and cardio-vascular complications.

About the Autors


Burmagina A.G. - nephrologist at State Budgetary Educational Institution of additional professional education Russian Medical Academy of post diploma Education of Russian Federation
Е-mail: a-burmagina@mail.ru;
Nikolaev A.Yu. - professor of nephrology and hemodialysis at State Budgetary Educational Institution of additional professional education Russian Medical Academy of post diploma Education of Russian Federation


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