Evaluation of the dynamics of the glomerular filtration rate in patients with chronic kidney disease according to the data of the regional register
O.N. Kurochkina, S.N. Kerimova, Z.B. Ismailov, T.A. Yagupova
1) Pitirim Sorokin Syktyvkar State University, Republic of Komi, Syktyvkar, Russia;
2) Komi Republican Oncological Dispensary, Republic of Komi, Syktyvkar, Russia;
3) Komi Republican Clinical Hospital, Republic of Komi, Syktyvkar, Russia
Background. Chronic kidney disease (CKD) is a global public health problem worldwide, associated with an increased risk of cardiovascular and all-cause mortality.
Objective. Identification of the regional features of the causes and rate of progression of CKD in the northern territory.
Material and methods. The data of the registry of 484 patients of the Nephrology Department of the Komi Republican Clinical Hospital for 2015–2018 were used; there were 231 (47.7%) men and 253 (52.3%) women. The mean age was 58.8±15.8 years.
Results. The number of patients with 1 visit – 314, with 2 or more visits – 170 patients. The mean glomerular filtration rate (GFR) was 30.1±19.3 ml/min/1.73 m2. Distribution by CKD stages: stage 1 CKD – 1.2%, 2 – 5.6%, 3a – 13.6%, 3b – 12.4%, 4 – 26.4% , 5 – 26.6%. The main causes of CKD: tubulointerstitial nephritis (21.5%), diabetic nephropathy (16.7%), chronic glomerulonephritis (15.7%), hypertensive nephropathy (12.0%), the diagnosis is not defined (12.8%). The average decrease in GFR was 3.99±2.7 ml/min/1.73 m2 during the year of follow-up. In patients with stage 2 CKD, GFR increased by 8.4 ml/min/1.73 m2 per year, with stage 3 CKD - a decrease by 0.13 ml/min/1.73 m2 per year, with stage 4 – decrease by 5.17, with stage 5 – decrease by 6.8 ml/min/1.73 m2 per year (p=0.034). A direct association of the rate of impairment of renal function with the level phosphate, urea, potassium, proteinuria, ESR levels, and an inverse association with the o hemoglobin, GFR levels was revealed. The most frequently prescribed drugs for the treatment of patients were angiotensin-converting enzyme inhibitors (32.4%), calcium channel blockers (47.5%), statins (36.4%), β-blockers (35.1%), diuretics (24, 6%), antiplatelet agents (39.9%).
Conclusion. Maintenance of a CKD registry allows to identify regional features of CKD and assess the rate of progression of CKD.
About the Autors
Olga N. Kurochkina – Professor at the Department of Therapy, Medical Institute, Pitirim Sorokin Syktyvkar State University. Address: 55 Oktyabrsky Prospect, Syktyvkar, Republic of Komi, Northwestern Federal District, 167001; e-mail: email@example.com. ORCID: 0000-0003-1595-7692
Tatyana A. Yagupova – Head of the Nephrology Department of the Komi Republican Clinical Hospital, Chief Freelance Expert in Nephrology of the Ministry of Health of the Komi Republic. Address: 114 Pushkin st., Syktyvkar, 167004; e-mail: firstname.lastname@example.org
Zaur B. Ismailov – Senior Laboratory Assistant at the Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences. Address: 24 Communist st., Syktyvkar, Republic of Komi, Russian Federation, 167982; e-mail: email@example.com. ORCID: 0000-0002-2686-3424
Sevil N. Kerimova – Oncologist of the Department of Antitumor Drug Therapy, Komi Republican Oncological Dispensary. Address: 46 Nyuvchimskoe sh., Krasnozatonsky town settlement, Syktyvkar, Republic of Komi, 167904. ORCID: 0000-0002-8155-2522