Renal function parameters and endothelial disfunction in patients with arterial hypertension


Rebrov A.P.,Kuklina A.L.

State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky, Ministry of Health of Russia, Saratov
Aim. Characteristics of renal glomerular and tubular disfunction in arterial hypertension.
Methods. 94 patients with arterial hypertesnion (age 30-65 years) were included into the study. Beyond standard clinical investigation, 24-hour blood pressure monitoring and arterial stiffness measurement were performed.
Results. Chronic kidney disease (CKD) was detected in 39,1% of patients, 2/3 of them constantly received antihypertensive medications. Estimated glomerular filtration rate (eGFR) correlated with arterial hypertension, duration of arterial hypertension, carotid intima-media thickness, arterial stiffness parameters. Proteinuria was associated with maximal level and time index of systolic blood pressure. In patients with arterial hypertension duration <5 years microalbuminuria and elevation of urinary excretion of α-1 microglobulin were found.
Conclusion. Early diagnosis of renal involvement in arterial hypertension can be optimized by use of urinary markers of renal tubular damage.

About the Autors


Rebrov A.P. – professor, head of hospital therapy department of Medical Faculty, State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky, Ph.D.;
E-mail: andreyprebrov@yandex.ru;
Kuklina A.L - Ph.D. student at hospital therapy department of Medical Faculty, State Budgetary Educational Institution of High Professional Education Saratov State Medical University named after V. I. Razumovsky.


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