Prevalence of chronic kidney disease in comorbid patients


D.O. Dragunov, A.V. Sokolova, T.V. Latyshev, G.P. Arutyunov

Purpose. Evaluation of detection rate and prevalence of CKD in comorbid patients with risk factors for CKD in outpatient clinical practice.
Material and Methods. 1000 out-patient medical records were analyzed. The study included 337 patients with two diseases, the first of which was arterial hypertension, and the second - coronary artery disease or diabetes mellitus. GFR was calculated using CKD-EPI formula in accordance with national guidelines for CKD. The diagnosis of CKD was verified in accordance with the KDIGO recommendations.
Results. The mean age of the patients was 75 ± 7.4 years. Mean estimated GFR using formula CKD-EPI was 77.5 ± 20 mL / min / 1,73m2. Of 337 patients enrolled in the study, 43% of patients were diagnosed with CKD, including C2 stage in 18.7% , C3 in 24% , and C4 - in 0.3% of patients. OR for the development of CKD in DM2 patients was 8.24 (95% CI 4.095 – 16.58; P <0,05). The risk of III FC stenocardia was higher in patients with CKD: OR 2.286 (95% CI 1.129- 4.626, P <0.05), but the risk of myocardial infarction in these patients was not high (OR 0.444; 95% CI 0.251 - 0.789).
Conclusion. Despite the high risk of CKD in all examined patients, none was diagnosed with CKD. Probably, this is due to the fact that the majority of patients had a second and third stage CKD, and it is known that these stages in most cases have not any nephrological symptoms, and often the an increase in blood pressure is the only sign.

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