Prevalence and pathogenesis of kidney damage in non-alcoholic fatty liver disease – the possibilities of early diagnosis using fluorescence organoscopy


DOI: https://dx.doi.org/10.18565/nephrology.2025.1.86-94

Lelyavina T.A., Galagudza M.M., Sonin D.L., Popov S.V., Guseinov R.G., Beshtoev A.Kh., Malyshev E.A.

1) Almazov National Medical Research Center, Saint Petersburg, Russia; 2) Saint Luke Clinical Hospital, Saint Petersburg, Russia; 3) Saint Petersburg Medical and Social Institute, Saint Petersburg, Russia; 4) Saint Petersburg State University, Saint Petersburg, Russia
Due to the increasing prevalence of obesity and diabetes worldwide, the overall incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is expected to increase. Risk factors for NAFLD are associated with the development of chronic kidney disease (CKD). This article discusses the epidemiology, risk factors, genetics, and specific pathogenetic mechanisms linking NAFLD with CKD: ectopic lipid accumulation, cellular signaling disorders, the relationship between fructose consumption and uric acid accumulation, etc. The possibilities of early diagnosis of these pathological conditions using fluorescence organoscopy are discussed.
Keywords: fluorescence organoscopy, non-alcoholic fatty liver disease, chronic kidney disease
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About the Autors

Lelyavina T.A. – Dr.Sci. (Med.), Leading Researcher, Research Institute of Myocardial Microcirculation and Metabolism, Institute of Experimental Medicine, Almazov National Medical Research Center. Address: St. Petersburg, 198992; e-mail: tatianalelyavina@mail.ru. ORCID: https:// orcid.org/0000-0001-6796-4064.
Galagudza M.M. –Dr.Sci. (Med.), Professor and Corresponding Member of the Russian Academy of Sciences, Director of the Institute of Experimental Medicine,
Almazov National Medical Research Center. Address: 198992, Akkuratova str, 2, St. Petersburg, Russia
Sonin D.L. – Cand.Sci. (Med.), Head of Research Institute of Myocardial Microcirculation and Metabolism, Almazov National Medical Research Center.
Address: 198992, Akkuratova str, 2, St. Petersburg, Russia.
Popov S.V. – Dr.Sci. (Med.), professor, Chief of the Saint Petersburg City Hospital Saint Luka, Head of the Center of Endourology and New Technologies.
Address: 194044, St. Petersburg, Chugunnaya St., 46; e-mail: doc.popov@gmail.com. ORCID iD 0000-0003-2767-7153.
Guseinov R.G. – Cand.Sci. (Med.), Deputy Director on Scientific work of «City Hospital Saint Luka», senior tutor of the Department of Surgery and Urology.
Address: 46 Chugunnaya St., St. Petersburg, 194044; Tel e- mail: rusfa@yandex.ru. ORCID iD 0000-0001-9935-0243
Beshtoev A.Kh. – Researcher, St. Petersburg State Budgetary Healthcare Institution, St. Luke’s Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044;
Tel.: +7 (812) 576-11-08; e-mail: akhmed.beshtoev@gmail.com. ORCID: 0009-0004-9544-7944.
Malyshev E.A. – Researcher, St. Petersburg State Budgetary Healthcare Institution, St. Luke’s Clinical Hospital. Address: 46 Chugunnaya St., St. Petersburg, 194044;
tel.: +7 (812) 576-11-08; e-mail: malyshevyegor@gmail.com. ORCID: 0000-0001-6294-6182.


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