Aim. to evaluate the prognostic value of kidney damage in patients with ST-segment elevation acute myocardial infarction (STEMI) in a prospective 6-month observational study.

Material and Methods. A prospective 6-month observational study included 241 patients with STEMI. The kidney function was evaluated by calculating the creatinine clearance using the CKD-EPI formula. An evaluation of the effect of renal dysfunction on CAD outcomes for 6 months was carried out. The endpoints of the study included: hospital mortality, cardiovascular mortality during follow-up, readmissions for acute coronary syndrome (ACS).

Results. 41.1% of patients had renal dysfunction (GFR <60 mL/min). Hospital mortality was rec-orded in 9.5% of cases; the highest mortality rate was recorded in the group of patients with GFR <60 ml/min – 17.2%, while among patients with GFR> 60 ml/min – 4.2% (p=0.001). Hospital mor-tality with GFR from 45 to 59 ml/min was 6.3%, GFR from 30 to 44 ml/min – 42.9%, GFR from 15 to 29 ml/min – 60.0% (p<0.001). GFR <60 ml/min increases the risk of the combined primary end-point by 3 times (RR 95% 2.917 (1.360–6.254, p=0.006), GFR from 45 to 30 ml/min – by 8 times (RR 95% 7.714 (2,076–28,661, p=0,002), and GFR from 30 to 15 ml/min – by 10 times (RR 95% 10,286 (2,383–44,398, p=0,002).

Conclusions. In patients with STEMI, a decrease in GFR is an unfavorable predictor of fatal out-come within 6 months of follow-up.