Русский
The relationship of bendopnea and change in renal filtration function in patients with chronic heart failure
DOI: https://dx.doi.org/10.18565/nephrology.2020.1.27-32
D.O. Dragunov, A.V. Sokolova, A.D. Gasanova, G.P. Arutyunov
1) Pirogov Russian National Research Medical University, Moscow, Russia; 2) Research Institute of Healthcare Organization and Medical Management of the Moscow Healthcare Department, Moscow, Russia
Material and methods. The study included 104 patients with heart failure from the register "Management of chronic patients with multiple diseases"; the mean age of patients was 72.8±10.6 years. All patients underwent a test to determine the presence of a bendopnea symptom, calculating glomerular filtration rate (GFR) at baseline and after 2 years of follow-up. Two groups of patients were formed: group 1–67 (64.42%) patients with a positive bendopnea test, group 2–37 (35.58%) – with a negative bendopnea test.
Results. In the cohort studied, mean GFR was 59.2±16.9 ml/min/1.73 m2. At the inclusion visit, the prevalence of chronic kidney disease (CKD) did not significantly differ between groups. After two years of follow-up, 12 patients with CKD progression were identified in group 1, while in group 2 there were only three such patients. The construction of a logistic model made it possible to determine the significant effect of the presence of a bendopnea symptom on the CKD dynamics: the risk of an increase in the CKD stage increased by 1.29 times (P<0.0001) in patients of group 1.
Conclusion. Thus, the presence of a bendopnea symptom in patients with heart failure is a risk factor for the progression of CKD.
About the Autors
Dmitry O. Dragunov – PhD in Medical Sciences, Associate Professor at the Department of Propaedeutics of Internal Diseases, Faculty of Pediatrics, Pirogov Russian National Research University, Head of Organizational and Methodological Department for the Treatment, Research Institute of Healthcare Organization and Medical Management of the Moscow Healthcare Department; Moscow, Russia. E-mail: tamops2211@gmail.com, tel.: 8 (910) 463-40-39.
Anna V. Sokolova – PhD in Medical Sciences, Associate Professor at the Department of Propaedeutics of Internal Diseases Faculty of Pediatrics, Pirogov Russian National Research University; Moscow, Russia, Leading Specialist at the Organizational and Methodological Department for the Treatment, Research Institute of Healthcare Organization and Medical Management of the Moscow Healthcare Department; Moscow, Russia.
A.D. Gasanova – Teaching Assistant at the Department of Propaedeutics of Internal Diseases Faculty of Pediatrics, Pirogov Russian National Research University; Moscow, Russia, Specialist at the Organizational and Methodological Department for the Treatment, Research Institute of Healthcare Organization and Medical Management of the Moscow Healthcare Department; Moscow, Russia.
Grigory P. Arutyunov – Doctor of Medical Sciences, Professor, Corresponding Member of RAS, Head of the Department of Propaedeutics of Internal Diseases Faculty of Pediatrics, Pirogov Russian National Research University; Moscow, Russia.
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