Русский
IgA-nephropathy in Belarusian cohort. Сlinical and pathological peculiarities, factors, associated with unfavorable outcome
DOI: https://dx.doi.org/10.18565/nephrology.2022.3.25-33
Komissarov K.S., Krasko O.V., Dmitrieva M.V., Letkovskaja T.A., Lugovskaya M.A., Kalinovskaya J.I., Pilotovich V.S.
1) Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology, Minsk, Republic of Belarus; 2) United Institute of Informatics Problems of the National Academy of Science of Belarus, Misnk, Republic of Belarus; 3) Belarusian State Medical University, Minsk, Republic of Belarus; 4) City Clinical Pathology Bureau, Minsk, Republic of Belarus; 5) 4th City Clinical Hospital named after M. Sauchanka, Minsk, Republic of Belarus; 6) 1st City Clinical Hospital, Minsk, Republic of Belarus; 7) Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of Belarus
Material and methods. It was multicenter clinical trial of 291 patients (31±11 years old, 65,6% male) with IgAN and initial proteinuria 1,0 [0,42–1,80] g/day, GFR 85 [65–102] ml/min, arterial hypertension 47,4%. 90% of the patients were treated with ACE inhibitors.
Results. Multivariate regression analysis revealed independent predictors of unfavorable outcome: arterial hypertension (HR=2,8; p=0,04), GFR<0 ml/min (HR=6,8; p=0,001), tubular atrophy and interstitial fibrosis (T) 26–50% (HR=3,0; p=0,015), T>50% (HR=6,6; p=0,001). The composite 5-, 10-year survival without dialysis and 50% decreasing GFR were 75,7±4 and 47,2±6,8%, respectively.
Conclusion. IgAN has an unfavorable course of disease in Republic Belarus.
About the Autors
Kirill S. Komissarov –Cand. Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, 1Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology. Address: 8 Semashko str., Minsk; tel: +3 (7517) 277-20-35, + 3 (7529) 680-70-97,
e-mail: kirill_ka@tut.by. ORCID: http://orcid.org/0000-0002-2648-0642.
Olga V. Krasko – Cand.Sci. (Engineering), Associate Professor, Leading Researcher at the Bioinformatics Laboratory, 2United Institute of Informatics Problems
of the National Academy of Science of Belarus. Address:, 6 Surganov str., Minsk; e-mail: olga.krasko.ok@gmail.com. ORCID: http://orcid.org/0000-0002-4150-282X.
Margarita V. Dmitrieva – Cand.Sci. (Med.), Teaching Assistant at the Department of Pathological Anatomy, Belarusian State Medical University. Address: 60 Kizhevatov str., Minsk; tel.: +3 (7517) 398-72-37; e-mail: mvdmitieva@inbox.ru. ORCID: http://orcid.org/0000-0002-2958-9424.
Tatyana A. Letkovskaja – Associate Professor, Head of the Department of Pathological Anatomy, Belarusian State Medical University. Address: 60 Kizhevatov str., Minsk; tel.: +3 (7517) 398-72-37; e-mail: taletkovskaya@mail.ru. ORCID: http://orcid.org/0000-0002-9381-2985. Maria A. Lugovskaya – Nephrologist, City Nephrology Center, 4th City Clinical Hospital named after N.E. Savchenka.
Address: 110 R.Lyuksemburg str., Minsk; tel.: +3 (7517) 208-28-63; e-mail: marielugovskaya@gmail.com.
Yuliya I. Kalinovskaya – Nephrologist, Department of Nephrology, 1st City Clinical Hospital. Address: 64 Independence Avenue, Minsk; tel.: +3 (7517) 379-05-50; e-mail: plyutay@yandex.ru.
Valery S. Pilotovich – Dr. Sci. (Med.), Professor at the Department of Urology and Nephrology,7Belarusian Medical Academy of Postgraduate Education. Address: 64 Independence Avenue, Minsk; tel.: +3 (7517) 265-25-61; e-mail: pilotovich@mail.ru. ORCHID: http://orcid.org/0000-0001-8256-5889.
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