Русский
Dynamic monitoring of the cardiovascular system and kidney function in patients with chronic kidney disease who had COVID-19
DOI: https://dx.doi.org/10.18565/nephrology.2022.4.13-18
Zhmurov D.V., Zhmurov V.A., Petrov I.M., Petelina T.I., Gapon L.I., Yaroslavskaya E.I., Petrova Yu.A., Reshetnikova T.V., Tolstoukhova N.V., Zhmurova E.A., Ermakova A.A., Ermakova P.A.
1) Tyumen State Medical University, Tyumen, Russia; 2) Tyumen Cardiology Research Center – Branch Campus of the Tomsk National Medical Research Center, Tyumen, Russia
Material and methods. A clinical follow-up and examination of 150 patients with CKD who have had COVID-19 was carried out. The examination included an assessment of the cytokine profile (interleukin-1 - IL-1, IL-6, IL-8, tumor necrosis factor a – TNF-a), determination of the of high-sensitivity C-reactive protein (CRP), ferritin, natriuretic peptide, cystatin C levels, echocardiogram, 24-hour blood pressure monitoring, estimation of the glomerular filtration rate according to the CKD-EPI formula during 12-month follow-up period.
Results. A change in the pro-inflammatory cytokine levels, an increase in the CRP level, a change in the structural and functional state of the cardiovascular system in patients at 3 and 12 months after COVID-19 were found. There was no significant deterioration in the functional state of the kidneys in patients after 3 months, while after 12 months of follow-up, the number of patients with advanced CKD stages increased, especially in the group of patients with CKD and cardiovascular diseases.
Conclusion. Patients with CKD who have had COVID-19 need for long-term follow-up by the nephrologist and cardiologist for comprehensive monitoring of the functional state of the kidneys and the cardiovascular system and adequate cardio- and nephroprotective therapy.
About the Autors
Denis V. Zhmurov – Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases, Tyumen State Medical University. Address: 54 Odesskaya st., Tyumen, 625023; e-mail: zhmdenis@yandex.ru.
Vladimir A. Zhmurov – Dr.Sci. (Med.), Professor, Head of the Department of Propaedeutics of Internal Diseases, Tyumen State Medical University, Tyumen; e-mail: zhmurovva@yandex.ru.
Ivan M. Petrov – Dr.Sci. (Med.), Associate Professor, Head of the Department of Medical Informatics and Biological Physics, Tyumen State Medical University, Tyumen. Tatyana I. Petelina – Dr.Sci. (Med.), Leading Researcher, Department of Arterial Hypertension and Coronary Artery Insufficiency, Scientific Department of Clinical Cardiology, Tyumen Cardiology Research Center - Branch Campus of the Tomsk National Medical Research Center, Tyumen.
Lyudmila I. Gapon – Dr. Sci. (Med.), Professor, Head of the Scientific Department of Clinical Cardiology, Scientific Director of the Department of Arterial Hypertension, Tyumen Cardiology Research Center - a Branch Campus of the Tomsk National Medical Research Center, Tyumen.
Elena I. Yaroslavskaya – Dr.Sci. (Med.), Head of the Laboratory of Instrumental Diagnostics, Tyumen Cardiology Research Center – a Branch Campus of the Tomsk National Medical Research Center, Tyumen.
Yulianna A. Petrova – Can.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases, Tyumen State Medical University, Tyumen.
Tatyana V. Reshetnikova– Can.Sci. (Med.), Associate Professor at the Department of Internal Propaedeutics, Tyumen State Medical University, Tyumen.
Natalya V. Tolstoukhova – Can.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases, Tyumen State Medical University, Tyumen. Ekaterina A. Zhmurova – 1-year resident physician at the Department of Internal Medicine, Polyclinic Therapy and Family Medicine, Tyumen State Medical University, Tyumen.
Anna A. Ermakova – Department of Propaedeutics of Internal Diseases, Tyumen State Medical University, Tyumen; e-mail: ermackovaanka@yandex.ru.
Polina A. Ermakova – Department of Propaedeutics of Internal Diseases, Tyumen State Medical University, Tyumen; e-mail: poli263@mail.ru.
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