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The effectiveness of hydroxychloroquine and its effect on cell-mediated and humoral immunity in patients with immunoglobulin A nephropathy: results of a prospective controlled study
DOI: https://dx.doi.org/10.18565/nephrology.2022.4.19-26
Komissarov K.S., Nizheharodava D.B., Minchenko E.I., Ivanchik G.I., Pilotovich V.S., Zafranskaya M.M.
1) Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology, Minsk, Republic of Belarus; 2) Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of Belarus; 3) First City Clinical Hospital, Minsk, Republic of Belarus; 4) International State Ecological Institute named after A.D. Sakharov, Belarusian State University, Minsk, Republic of Belarus
Material and methods. Using flow cytometry and enzyme immunoassay methods, clinical, laboratory and immunological parameters were determined in 3 groups of patients with IgAN with glomerular filtration rate >50 ml/min and proteinuria (PU) >1 g/day: group 1 - HCQ (n=20), group 2 - GCS (n=20) and group 3 - maintenance therapy (n=12).
Results. A six-month course of HCQ reduced the PU level (P=0.03), the relative number of TNK-cells (P=0.05) and γδT-lymphocytes (p=0.01), as well as their cytotoxic profile, and also reduced the serum APRIL factor and immunoglobulin levels in patients with IgAN (P = 0.05), which led to remission in 60% of patients.
Conclusion. HCQ can be used as an effective alternative therapy in patients with IgAN.
About the Autors
Kirill S. Komissarov – Cand. Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko st., Minsk; tel.: +(37517) 277-20-35, + (37529) 680-70-97; e-mail: kirill_ka@tut.by. ORCID: 0000-0002-2648-0642.
Daria B. Nizheharodava – Cand. Sci. (Biol.), Associate Professor, Head of the Department of Immunology and Biomedical Technologies, Research Laboratory, Belarusian Medical Academy of Postgraduate Education. Address: bldg. 3, 3 P. Brovka st., Minsk; tel.: + (37517) 390-22-32, + (37529) 608-99-94; e-mail: nzh@tut.by. ORCID: 0000-0003-1633-7487.
Elena I. Minchenko – Nephrologist, Department of Nephrology, First City Clinical Hospital. Address: 64 Independence Ave., Minsk; tel.: +(37517) 379-05-50; e-mail: elena_nefro@mail.ru. ORCID: 0000-0001-6268-7563.
Galina I. Ivanchik – Senior Researcher at the Department of Immunology and Biomedical Technologies of the Research Laboratory, Belarusian Medical Academy of Postgraduate Education. Address: Address: bldg. 3, 3 P. Brovka st., Minsk; tel. +(37517) 390-33-56; e-mail: immunology.by@gmail.com.
Valery S. Pilotovich – Dr. Sci. (Med.), Professor at the Department of Urology and Nephrology, Belarusian Medical Academy of Postgraduate Education. Address: bldg. 3, 3 P. Brovka st., Minsk; tel.: +(37517) 265-25-61; e-mail: pilotovich@mail.ru. ORCHID: 0000-0001-8256-5889.
Marina M. Zafranskaya – Dr. Sci. (Med.), Professor, Head of the Department of Immunology, International State Ecological Institute n.a. A.D. Sakharov, Belarusian State University. Address: bldg. 1, 23 Dolgobrodskaya st., Minsk; tel. + (37517) 243-00-07, + (37529) 631-25-48; e-mail: zafranskaya@gmail.com.
ORCHID: 0000-0002-8739-8300.
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