Objective. Evaluation of the participation of pro-inflammatory cytokines in cardiovascular calcification, identification of the relationship with the risk of its development in patients with chronic kidney disease (CKD) receiving renal replacement therapy (RRT).
Material and methods. A one-time examination of 85 CKD patients om program hemodialysis was carried out. The blood interleukin-3 (IL-3), IL-6 levels were determined using ELISA; white blood cell (WBC) shift index, and systemic inflammation risk index according to the Glasgow Prognostic Score (GPS) were calculated. Cardiovascular calcification (CVC) was divided into aortic wall calcification (AWC), heart valves (HVC), any calcification (AWC and/or HVC) or concomitant valvular and aortic calcification (AWC+HVC). Statistical analysis was carried out using the Statistica 12.6.
Results. A significant correlation between the risk of the aorta and heart valve calcification (AWC + HVC) with the IL-3 and IL6 levels (P<0.05) was established. Increase in IL-3 level (more than 35 pg/ml) led to the most pronounced increase in the risk of concomitant calcification (AWC + HVC). The prognostic value of IL-3 was decreased, while IL-6 persistent in the presence of any component of the calcifications of the aorta and heart valves: AWC or HVC. The effect of WBC shift index on the risk of CVC was detected both in relation to concomitant and isolated calcification (P<0.05). The relationship of the systemic inflammation risk index was established in relation to concomitant calcification (P<0.05).
Conclusion. Determining the pro-inflammatory cytokine levels in CKD has the potential to identify patients at risk for CVC. IL-6, IL-3 are involved in the cytokine regulation of CVC in CKD patients.

Keywords: interleukin-3, cardiovascular calcification, interleukin-6