Arterial hypertension in kidney transplantation – modern treatment strategy
DOI: https://dx.doi.org/10.18565/nephrology.2023.4.53-59
Nosov V.P., Koroleva L.Yu., Solovyanova E.N.
Privolzhsky Research Medical University, Nizhny Novgorod, Russia
Arterial hypertension (AH) is the most common cardiovascular risk factor in kidney transplant recipients. Post-transplant hypertension refers to a persistent increase in blood pressure (BP) or a normotensive state during antihypertensive therapy after successful kidney transplantation. Post-transplant hypertension, being a leading risk factor for coronary artery disease (CAD), stroke and congestive heart failure in kidney transplant recipients, is accompanied by a decrease in survival, mainly due to the addition of CAD. Thus, kidney transplantation and hypertension, according to an analysis of the French national database, increase the risk of developing myocardial infarction, mainly without ST segment elevation, by 1.45 times during the first 5 years. In general, every 20 mmHg increase in systolic blood pressure. over 140 mm Hg. associated with a 32% increase in the incidence of major cardiovascular events. The main goal of therapy for post-transplant hypertension is the prevention of cardiovascular complications and hypertensive damage to the renal allograft. The difficulty of therapy is associated with the associated multiple comorbidity, forced polypharmacy, and a certain pathogenetic stage, which requires a multidisciplinary approach.
About the Autors
Vladimir P. Nosov – Dr.Sci. (Med.), Professor at the Department of Hospital Therapy and Emergency Medicine named after. V.G. Vogralik, Privilzhsky Research Medical University. Address: BOX-470 10/1 Minin and Pozharsky sq., Nizhny Novgorod, 603950
Lyubov Yu. Koroleva – Dr.Sci. (Med.), Professor at the Department of Hospital Therapy and General Preparations named after. V.G. Vogralik, Privilzhsky Research Medical University. Address: BOX-470 10/1 Minin and Pozharsky sq., Nizhny Novgorod, 603950.
Elena N. Solovyanova – Cand. Sci. (Med.), Associate Professor at the Department of Hospital Therapy and Emergency Medicine named after. V.G. Vogralik, Privilzhsky Research Medical University. Address: BOX-470 10/1 Minin and Pozharsky sq., Nizhny Novgorod, 603950, e-mail: elenas-nn@mail.ru
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