Русский
Biological significance of differentially expressed genes in hypoxic-ischemic acute kidney
DOI: https://dx.doi.org/10.18565/nephrology.2024.2.61-67
S.V. Popov, R.G. Guseinov, A.M. Yesayan, O.N. Skryabin, A.V. Vasin, A.V. Kovalevskaya, V.V. Perepelitsa, A.Kh. Beshtoev, T.A. Lelyavina
1) St. Luke's Clinical Hospital, St. Petersburg, Russia; 2) S. M. Kirov Military Medical Academy, St. Petersburg, Russia; 3) St. Petersburg State University, St. Petersburg, Russia; 4) Smorodintsev Research Institute of Influenza, St. Petersburg, Russia; 5) Pavlov University, St. Petersburg, Russia; 6) St. Petersburg Medical and Social Institute, St. Petersburg, Russia; 7) Peter the Great St. Petersburg Polytechnic University, Institute of Biomedical Systems and Biotechnologies, St. Petersburg, Russia; 8) Almazov National Medical Research Center, St. Petersburg, Russia
Material and methods. This article analyzes literature sources on the significance of biomarkers with proven changes in the expression level in AKI.
Results. The diversity of pathogenetic mechanisms determines the participation of many genes in the cascade of pathological reactions that lead to AKI. Genetic profiling aimed at searching for genetic determinants of AKI will provide early identification of patients at risk and personalized preventive measures in accordance with the modern model of patient-centered medicine.
Conclusion. To date, however, genetic variants of biomarkers of kidney damage and their relationship with susceptibility to AKI have not been determined, and diagnostic panels of expression of genetic biomarkers of kidney damage are not used in routine clinical practice.
About the Autors
Sergey V. Popov – Dr.Sci. (Med.), Professor, Chief Physician of St. Luke's Clinical Hospital, Head of the Center for Endoscopic Urology and New Technologies, Professor at the Department of Urology, S.M. Kirov Military Medical Academy. Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: doc.popov@gmail.com. ORCID: 0000-0003-2767-7153.
Ruslan G. Guseinov – Cand.Sci. (Med.), Deputy Chief Physician for Scientific Activities, St. Luke's Clinical Hospital, Teaching Assistant at the Department of Hospital Surgery, St. Petersburg State University. Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (812) 576-11-08; e-mail: rusfa@yandex.ru. ORCID: 0000-0001-9935-0243.
Ashot M. Yesayan – Dr.Sci. (Med.), Professor, Head of the Department of Nephrology and Dialysis, Faculty of Postgraduate Education, Pavlov University, Chief External Expert in Nephrology of the North-Western Federal District of the Russian Federation. Address: 17 L.Tolstoy st. St. Petersburg, 197022; tel.: +7 (812) 338-69-20;
e-mail: essaian.ashot@gmail.com. ORCID: 0000-0002-7202-3151.
Oleg N. Skryabin – Dr.Sci. (Med.), Professor, Chief Oncologist of St. Luke's Clinical Hospital, Scientific Director of the Center for Endoscopic Urology and New Technologies. Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (812) 576-11-08; e-mail: skryabin_55@mail.com.ORCID: 0000-0002-6664-2861. 0000-0003-4064-5033.
Andrey V. Vasin – Director of the Institute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, Doctor of Biological Sciences, Associate Professor, Professor of the Russian Academy of Sciences. Address: 11 Khlopin st., St. Petersburg, 194021; tel.: +7 (812) 290-95-00;
e-mail: vasin_av@spbstu.ru. ORCID: 0000-0002-1391-7139.
Anastasia V. Kovalevskaya – Nephrologist, St. Luke’s Clinical Hospital. Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: stenia1407@mail.ru. ORCID: 0009-0004-9544-7944.
Vitaly V. Perepelitsa – Cand.Sci. (Med.), Urologist, St. Luke’s Clinical Hospital. Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: perepelitsa_vit@mail.ru. ORCID: 0000-0002-7656-4473.
Akhmed Kh. Beshtoev – Research Intern, St. Luke's Clinical Hospital. Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (812) 576-11-08;
e-mail: akhmed.beshtoev@gmail.com.
Tatyana A. Lelyavina – Leading Researcher at the Institute of Electronic Experiments, Almazov NMRC, Researcher at St. Luke's Clinical Hospital.
Address: 46 Chugunnaya st., St. Petersburg, 194044; tel.: +7 (891) 908-90-18; e-mail: tatianalelyavina@mail.com. ORCID: 0000-0001-6796-4064.
Similar Articles
