Clinical relevance of determination of neutrophil gelatinase-associated lipocalin-2 in children with acute kidney injury


A.V. Eremeeva, V.V. Dlin, A.A. Korsunsky, N.M. Zaikova, E.D. Bondarenko, E.V. Kondrikova

1 FSAEI HE «First Moscow State Medical University n.a. I.M. Sechenov» of RMH; Moscow, Russia; 2 SAB «Scientific Research Clinical Institute of Pediatrics n.a. Academician Yu.E. Veltischev» FSBEI HE «Russian National Scientific Medical University n.a. N.I. Pirogov» of RMH; Moscow, Russia
Improvement of methods for diagnosis and prediction of acute kidney injury is associated with the identification and evaluation of new biomarkers associated with early stage acute kidney injury and independent of the filtration renal function. The article presents data on the evaluation of the role of neutrophil gelatinaseassociated lipocalin in the diagnosis of acute kidney injury. The results of a number of studies that demonstrate the reliable efficacy of NGAL as a biomarker for predicting the risk of developing acute kidney injury and renal tubular damage are analyzed. Detection of NGAL in the urine and blood can reflect the active damage of the renal tubules, predict a decrease in the glomerular filtration rate and, thereby, predetermine the progression of the disease. It has been established that blood and urine NGAL levels is a prognostically significant biomarker of the course of acute kidney damage of different etiology in both children and adults.
Keywords: NGAL, neutrophil gelatinase-associated lipocalin, acute kidney injury
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About the Autors

Eremeeva A.V. – PhD in Medical Science, Associate Professor at the Department of Pediatrics and Children’s Infectious Diseases FSAEI HE "First Moscow State Medical
University n.a. I.M. Sechenov" of RMH; Moscow, Russia. E-mail: alinaeremeeva@yandex.ru
Dlin V.V. – Doctor of Medical Sciences, Professor, Deputy Director for Scientific Work SAB SRCI of Pediatrics n.a. Academician Yu.E. Veltischev FSBEI HE "RNSMU n.a.
N.I. Pirogov" of RMH; Moscow, Russia. E-mail: vvdlin@mail.ru
Korsunsky A.A. – Doctor of Medical Sciences, Professor, Head of the Department of Pediatrics and Children’s Infectious Diseases FSAEI HE "First Moscow State Medical
University n.a. I.M. Sechenov" of RMH; Moscow, Russia. E-mail: dr_kaa@mail.ru
Zaikova N.M. – PhD in Medical Science, Teaching Assistant at the Department of Pediatrics and Children’s Infectious Diseases FSAEI HE "First Moscow State Medical
University n.a. I.M. Sechenov" of RMH; Moscow, Russia. E-mail: nataliazaikova@mail.ru
Bondarenko E.D. – Teaching Assistant at the Department of Pediatrics and Children’s Infectious Diseases FSAEI HE "First Moscow State Medical University n.a. I.M.
Sechenov" of RMH; Moscow, Russia. E-mail: alenkabond@gmail.com
Kondrikova E.V. – PhD in Medical Science, Associate Professor at the Department of Pediatrics and Children’s Infectious Diseases FSAEI HE "First Moscow State Medical
University n.a. I.M. Sechenov" of RMH; Moscow, Russia. E-mail: e.kondrikova@mail.ru


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