Русский
Dynamics of inflammatory biomarkers in hospitalized patients with acute kidney injury during COVID-19
DOI: https://dx.doi.org/10.18565/nephrology.2022.2.64-68
S.A. Perepelitsa, L.V. Mikhailova, K.G. Shcherbanev, F.G. Yunusova
1) Immanuel Kant Baltic Federal University, Medical Institute, Kaliningrad, Russia; 2) V.A. Negovsky Research Institute of General Reanimatology, Federal Research Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
Material and methods. The retrospective study included 437 patients admitted to an infectious diseases hospital with a confirmed diagnosis of COVID-19. In dynamics, the serum creatinine, ferritin, lactate dehydrogenase (LDH), C-reactive protein (CRP) levels were assessed, the level of interleukin-6 (IL-6) was assessed at admission. Acute kidney injury (AKI) was diagnosed according to the KDIGO (2012) criteria.
Results. It was revealed that 76 (20.5%) examined patients had signs of AKI. The CRP, ferritin and LDH levels at admission and on the 3rd day after were higher in patients with AKI, and on the 5th and 10th day only an increase in the LDH level remained statistically significant. The level of IL-6 at admission was also higher in the group of patients with AKI.
Conclusion. Hospitalized patients with AKI associated with COVID-19 had higher plasma levels of inflammatory biomarkers. The high incidence of AKI in the COVID-19 hospitalized population necessitates monitoring of renal function parameters at the outpatient stage after discharge.
About the Autors
Svetlana A. Perepelitsa – Dr.Sci. (Med.), Professor at the Department of Surgical Disciplines, Medical Institute, Immanuel Kant Baltic Federal University. Address: 4/6 Botkin st., Kaliningrad, Kaliningrad region, 236016. Leading researcher at the V.A. Negovsky Research Institute of General Reanimatology, Federal Research Clinical Center of Intensive Care Medicine and Rehabilitology. Address: Building 2, 25 Petrovka st., Moscow, 107031; e-mail: sveta_perepeliza@mail.ru.. ORCID: 0000-0002-4535-9805.
Larisa V. Mikhailova – Cand. Sci. (Med.), Associate Professor, Department of Therapy, Medical Institute, Immanuel Kant Baltic Federal University. Address: 4/6 Botkin st., Kaliningrad, Kaliningrad region, 236016; e-mail: mihalysa@mail.ru.. ORCID: 0000-0001-5070-5955.
Kirill G. Scherbanev – 1st-year Resident in the specialty "Therapy", Medical Institute, Immanuel Kant Baltic Federal University. Address: 4/6 Botkin st., Kaliningrad, Kaliningrad region, 236016; e-mail: sherbanev1997@mail.ru.. ORCID: 0000-0002-4230-1974.
Fatima G. Yunusova – 1st-year Resident in the specialty "Therapy", Medical Institute, Immanuel Kant Baltic Federal University. Address: 4/6 Botkin st., Kaliningrad, Kaliningrad region, 236016; e-mail: yunusovafati@yandex.ru.. ORCID: 0000-0003-4353-7521.
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