Clinical Nephrology » Clinical cases of acute kidney injury under conditions of exposure to short-term abnormal heat waves

Clinical cases of acute kidney injury under conditions of exposure to short-term abnormal heat waves

DOI: https://dx.doi.org/10.18565/nephrology.2025.1.53-60

Murkamilov I.T., Aitbaev K.A., Fomin V.V., Yusupov F.A., Yusupova T.F., Yusupova Z.F., Duysheeva G.K., Khakimov Sh.Sh., Solizhonov Zh.I., Ymankulov D.S.
1) Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyzstan; 2) Salymbekov University, Bishkek, Kyrgyzstan; 3) Research Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan; 4) Sechenov University, Moscow, Russia; 5) Osh State University, Osh, Kyrgyzstan; 6) Kazan State Medical University, Kazan, Russia; 7) Green Clinic Medical Center, Bishkek, Kyrgyzstan

In recent years, Central Asia has seen an increase in the incidence of abnormally hot summer days, which is associated with an increased risk to public health. Exposure to elevated temperatures significantly affects the incidence of cardiovascular, respiratory, and renal diseases, which is reflected in an increase in mortality. Unlike cold, heat leads to rapid implementation of pathological changes with a shorter time lag and shorter waves. Heat waves are traditionally associated with heat stroke, heat syncope, as well as decompensation of chronic non-communicable diseases and the development of acute kidney injury (AKI). In conditions of abnormal heat, the renin-angiotensin-aldosterone and sympathetic nervous systems are activated, which is a physiological response to high temperatures. Individuals with chronic non-communicable diseases are especially susceptible to the negative effects of heat. The article presents the results of two clinical cases of AKI, the development of which occurred against the background of abnormal heat in patients with chronic diseases. Both patients showed an increase in creatinine, homocysteine, and serum interleukin-6 levels. During treatment, stabilization of the renal filtration function and a decrease in the interleukin-6 level were noted.

Keywords: toxic nephropathy, abnormal heat, climate, chronic kidney disease, acute kidney injury

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About the Autors

Ilkhom T. Murkamilov – Dr.Sci. (Med.), Associate Professor at the Department of Faculty Therapy, KSMA named after I.K. Akhunbaev; Director of the multidisciplinary
medical center «Doc university clinic», Salymbekov University. Address: 92 Akhunbaev St., Bishkek, 720020. 92; Tel.: (+996) 557-221-983; E-mail: murkamilov.i@mail.ru. ORCID: https://orcid.org/0000-0001-8513-9279.
Kubanych A. Aitbaev – Dr.Sci. (Med.), Professor, Head of the Department of Pathological Physiology, Research Institute of Molecular Biology and Medicine.
Address: 3 T. Moldo St., Bishkek, 720040; tel.: (+996) 555-758-476; e-mail: aitbaev.kuban1940@gmail.com. ORCID: https://orcid.org/0000-0003-4973-039X.
Viktor V. Fomin – Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy No. 1,
N.V. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Innovation and Clinical Activities, Sechenov University. Address: 2 Bolshaya Pirogovskaya St., Moscow, 119991;
tel.: (495) 609-14-00 ext. 2142; e-mail: fomin_vic@mail.ru. ORCID: https://orcid.org/0000-0002-2682-4417.
Furkat A. Yusupov – Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University.
Address: 331 Lenin St., Osh, 723500; Tel.: (+996) 990-999-291; E-mail: furcat_y@mail.ru. ORCID: https://orcid.org/0000-0003-0632-6653.
Tursunoy F. Yusupova – Clinical Resident at the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University. Address:
Address: 331 Lenin St., Osh, 723500; tel.: (+996) 707-130-938; e-mail: yusupova_tursunoy_f@mail.ru. ORCID: https://orcid.org/0000-0002-8502-2203.
Zulhumor F. Yusupova – 4th-year Student at the Faculty of Medicine, Osh State University. Address: 331 Lenin St., Osh, 723500; tel.: (+996) 707-130-938;
e-mail: zulkhumor.yusupova.f_05@mail.ru. ORCID: https://orcid.org/0000-0001-7621-1128.
Gulzat K. Duysheeva – Teaching Assistant of the Department of Faculty Therapy, KSMA named after. I.K. Akhunbaev. Address: 92 Akhunbaev str., Bishkek, 720020;
tel.: (+996) 770-252-528; e-mail: guzyu_88@mail.ru.
Shavkat Sh. Khakimov – Head of the Department of Resuscitation, Therapy and Diagnostics, Salymbekov University. Address: 144 Bokonbaev str., Bishkek, 720040,
tel.: (+996) 551-660-013; e-mail: hakimovshaki13@gmail.com. ORCID: https://orcid.org/0009-0004-0437-0188.
Zhaloliddin I. Solizhonov – 6th-year student at the Faculty of Medicine, Kazan State Medical University. Address: 49 Butlerov str., Kazan, 420012; tel.: (+495) 967-4690-0438; e-mail: jaloliddinsolijonov44@gmail.com. ORCID: https://orcid.org/0009-0003-0078-0609.
Daniyar S. Ymankulov – Researcher, Plastic Surgeon, Green Clinic. Address: 118 Isanov str., Bishkek, 720040; tel.: (+996) 551-196-991; e-mail: ymankulov9595@mail.ru. ORCID: https://orcid.org/0009-0000-4975-1196.

Clinical cases of acute kidney injury under conditions of exposure to short-term abnormal heat waves

About the Autors

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