Frequency and predictors of acute kidney injury in patients after surgical correction of heart valve disease


B.G. Iskenderov, O.N. Sysina

State Budgetary Educational Institution of High Professional Education “Penza Institute of Advanced medical education“Ministry of Health of Russian Federation
Aim. Determination of risk factors, outcomes and influence of early postoperative period of acute kidney injury (AKIN) in patients with normal glomerular filtration, undergone surgical correction of heart valve disease.
Methods. In 495 patients (283 male, 212 female) with acquired heart valve disease (mean age 53,7±6,3 years), after surgical correction according to the RIFLE criteria 87 (17,6%) patients had R (risk) criteria of AKIN, 52 (10,5%) – I (injury), 25 (5,1%) F (failure).
Results. AKIN was more often diagnosed in female patients (p=0,038); patients with AKIN were significantly older (p=0,021). Main predictors of AKIN were infective endocarditis, diabetes mellitus, chronic heart failure, atrial fibrillation, coronary heart disease and stroke. 53,0% patients had transient AKIN, 42,1% persistent, 4,9% – continuous. 9 (5,5%) of patients with AKIN in 6 month had GFR< 60 ml/min/1,73 m2. In-hospital and 6-month mortality was higher in patients with AKIN (7,9% vs 2,1%; 3,3% vs 0,9%).
Conclusion. More than 1/3 of patients with heart valve diseases undergone their surgical correction develop acute kidney injury, which is a risk factor for complications and mortality.

About the Autors


Iskenderov B.G. – professor at therapy, cardiology and functional diagnostic of State budgetary Educational Institution of High Professional Education “Penza Institute of Advanced medical education“Ministry of Health of Russian Federation, Ph.d.
E-mail: iskenderovbg@mail.ru,
Sysina O.N. – head of nephrology department of State budgetary Educational Institution of High Professional Education “Penza Institute of Advanced medical education“Ministry of Health of Russian Federation, Ph.d., associated professor


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