Bone mineral density, bone and phosphate-calcium metabolism parameters in patients with oxalate nephropathy in early stages of chronic kidney disease


N.V. Voronina, T.B. Agievich

Therapy and prophylactic medicine of postgraduate faculty SBEU HPE FESMU of Ministry of Healthcare of Russian Federation
Aim. Estimation of bone mineral density by densitometry in correlation with bone metabolism and calcium-phosphorus metabolism parameters in young patients with oxalate nephropathy and chronic kidney disease (CKD) 1–2 stage.
Methods. 102 patients with oxalate nephropathy and CKD 1–2 stage (age 18–40 years) were included into the study. X-Ray absorbtiometry (Dxa) was used for bone mineral density (BMD) measurement. Serum levels of osteocalcine, terminal C-peptide (β-CrossLaps), parathyreoid hormone (PTH), 25 hydroxyvitamine D D[25(ОН)D3], concentrations of calcium, phosphate, activity of alkaline phosphatase, creatinine were determined; glomerular filtration rate was calculated by Cockroft-Gault.
Results. Densitometry revealed decrease of bone mineral density in patients with oxalate nephropathy and CKD 1–2 stage. BMD decrease was associated with lowering of serum level of total calcium, elevation of total alkaline activity, PTH, osteocalcine and β-Cross Laps. Serum levels of 25(ОН)D3 and phosphate did not differ significantly from healthy controls.
Conclusion. Patients with oxalate nephropathy and chronic kidney disease 1–2 stage have osteopenia, which requires therapeutic correction.

About the Autors


Voronina N.V., MD, PhD, professor, head of therapy and prophylactic medicine of postgraduate faculty SBEU HPE FESMU of Ministry of Healthcare of Russian Federation
Agievich T.B., assistant professor of therapy and prophylactic medicine of postgraduate faculty SBEU HPE FESMU of Ministry of Healthcare of Russian Federation


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