New approaches in treatment of chronic kidney disease in metabolic syndrome


E.M. Shilov, E.I. Levankovskaya, M.S. Novikova

Nephrology and hemodialysis department at faculty of post diploma professional medical education at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation, Moscow
The determination of the dominant significance of the metabolic syndrome (MS) in the growth of the global prevalence of chronic kidney disease (CKD) has led to numerous studies that have demonstrated a strong association of the pathogenetic basis of this syndrome – insulin resistance (IR) and compensatory hyperinsulinemia – with a glomerular filtration rate. This allows suggesting that therapy aimed at reducing IR can slow the progression of CKD. The results of our studies not only confirm these data, but also demonstrate the possible significance of IR in the progression of nephrosclerosis and advanced stages of CKD. Positive effects of IR correction on course of nephropathy and risk factors for CKD, associated with IR, in patients with CKD and metabolic syndrome has been shown. Correction of IR led to decrease of hyperfiltration – the main nonimmune mechanism of progression of nephropathy and early sign of kidney involvement in the pathological process.

About the Autors


Shilov E. M. – professor, head of Nephrology and hemodialysis department at faculty of post diploma professional medical education at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation, Ph.D.
E-mail: emshilov@mma.ru;
Levankovskaya E.I. – Ph.D. Student at Nephrology and hemodialysis department at faculty of post diploma professional medical education at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation.
E-mail: e.levankovskaya@gmail.com;
Novikova M.S. – assistant at Nephrology and hemodialysis department at faculty of post diploma professional medical education at State Budgetary Educational Institution of High Professional Education “First Moscow State Medical University n.a. I.M. Sechenov” Ministry of Health and Social Development of Russian Federation, Ph.D.
E-mail: citrus7474@mail.ru


Similar Articles


Бионика Медиа