Predictors of chronic kidney disease in workers of locomotive crews


A.Ju. Lazutkina, V.V. Gorbunov

1 Regional Directorate of Medical Support for the Trans-Baikal Railroad, Chita; 2 SEI HPE “Chita State Medical Academy”
Purpose. To establish a causal relationship between the development and progression of chronic kidney disease in workers of locomotive crews.
Material and methods. In 2008–2013 7959 workers of railway train crews of Trans-Baikal Railway, undergoing periodic health assessments were examined for the presence of cardiovascular disease risk factors and target organ damage.
Results. Over the study period standard evaluation of subclinical manifestations of atherosclerosis in patients with kidney disease was carried out in 7959 subjects. Elevated creatinine levels was found in 116 cases, proteinuria and reduced glomerular filtration rate were observed in 8–6 cases. Statistical analysis showed that excessive alcohol intake, dyslipidemia, retinopathy, and family history of early cardiovascular disease led the development of proteinuria. Reduced glomerular filtration rate, retinopathy, body mass index and BMI≥25,0 were associated with the increase of serum creatinine level. Reduced glomerular filtration rate caused increase of serum creatinine level, hyperglycemia and atherosclerosis of the aorta.
Conclusion. The findings necessitate inclusion of tests for proteinuria, serum creatinine and GFR calculation in of mandatory health assessment of workers of locomotive crews as preventive measures for CKD and CVD.

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About the Autors


Information about the authors:
Lazutkina A.Ju. - Chief Inspector - Physician of Preventive Services Department of the Regional Directorate of Medical Support for the Trans-Baikal Railway
E-mail: lazutkina_au59@mail.ru
Gorbunov V.V. – Prof., Head of Department of Internal Medicine of SEI HPE “Chita State Medical Academy”, Ph.D.


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