Русский
Post-COvid Cytokine profile and cardiovascular status in patients with chronic kidney disease after COVID-19
DOI: https://dx.doi.org/10.18565/nephrology.2022.3.15-19
Zhmurov D.V., Zhmurov V.A., Petrov I.M., Petelina T.I., Gapon L.I., Yaroslavskaya E.I., Petrova Yu.A., Zhmurova E.A. , Ermakova A.A., Ermakova P.A.
1) Tyumen State Medical University, Tyumen, Russia; 2) Tyumen Cardiology Research Center - Branch of the Tomsk National Medical Research Center, Tyumen, Russia
Material and methods. Clinical follow-up and examination of 150 patients with CKD after COVID-19 was carried out. The examination included the determination of the interleukin-1 (IL-1), IL-6, IL-8, tumor necrosis factor a (TNF-a), transforming growth factor β (TgFβ1), hsCRP, D-dimer, fibrinogen, ferritin, natriuretic peptide, cystatin C levels, echocardiography, 24-hour blood pressure monitoring, calculation of the glomerular filtration rate according to the CKD-EPI formula.
Results. An increase in the pro-inflammatory cytokine levels, an increase in the hsCRP, D-dimer, fibrinogen, ferritin, natriuretic peptide levels, a change in the structural and functional state of the cardiovascular system (CVS) in patients, especially in the first 3 months after a coronavirus infection, were found. Significant deterioration of the functional state of the kidneys during 3 months of follow-up was not observed in the majority of patients.
Conclusion. Patients with CKD after new coronavirus infection require the supervision of a nephrologist and a cardiologist to monitor the functional state of the cardiovascular system and kidneys, as well as for the cardio- and nephroprotective therapy prescription.
About the Autors
Denis V. Zhmurov – Cand.Sci. (Med.), Associate Professor at the Department of Propaedeutic and Faculty Therapy, Tyumen State Medical University, Tyumen. Address: 54 Odesskaya st., Tymen, 625023; tel.: 8 (909) 181-31-04; e-mail: zhmdenis@yandex.ru.
Vladimir A. Zhmurov – Dr. Sci. (Med.), Professor, Head of the Department of Propaedeutic and Faculty Therapy, Tyumen State Medical University, Tyumen, e-mail: zhmurovva@yandex.ru.
Ivan M.Petrov – Dr. Sci. (Med.), Associate Professor, Head of the Department of Medical Informatics and Biological Physics with the UNESCO Bioethics Network Section, Tyumen State Medical University, Tyumen.
Tatyana I. Petelina – Dr. Sci. (Med.), Leading Researcher, Department of Arterial Hypertension and Coronary artery insufficiency, Scientific Department of Clinical Cardiology, Tyumen Cardiology Research Center - Branch of the Tomsk National Medical Research Center, Tyumen.
Lyudmila I. Gapon – Dr. Sci. (Med.), Professor, Head of the Scientific Department of Clinical Cardiology, Scientific Director of the Department of Arterial Hypertension, Tyumen Cardiology Research Center – Branch of the Tomsk National Medical Research Center, Tyumen.
Elena I. Yaroslavskaya – Dr. Sci. (Med.), Head of the Laboratory of Instrumental Diagnostics, Tyumen Cardiology Research Center –Branch of the Tomsk National Medical Research Center, Tyumen.
Yulianna A.Petrova – Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutic and Faculty Therapy, Tyumen State Medical University, Tyumen. Ekaterina A. Zhmurova – Medical Resident at the Department of Internal Medicine, Outpatient Therapy and Family Medicine, Tyumen State Medical University, Tyumen.
Anna A. Ermakova – Faculty of Medicine, Department of Propaedeutic and Faculty Therapy, Tyumen State Medical University, Tyumen; e-mail: ermackovaanka@yandex.ru. Polina A. Ermakova – Faculty of Medicine, Department of Propaedeutic and Faculty Therapy, Tyumen State Medical University, Tyumen; e-mail: poli263@mail.ru.
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