Comparative informativeness of proteinuria tests in patients with chronic obstructive pulmonary disease


E.V. Bolotova, A.V. Dudnikova

Objective. To evaluate the incidence of albuminuria among patients with COPD and assess the informativeness of different proteinuria tests.
Material and methods. The study included 200 patients of Krasnodar KCH №2 diagnosed with COPD. The patients were divided into four groups depending on the frequency and severity of exacerbations. All patients were tested for proteinuria using different tests: semi-quantitative «method of dry chemistry», quantification of protein with pyrogallol red, urinary albumin excretion, β2-microglobulin, and protein-creatinine and albumin-creatinine ratios.
Results. The semiquantitative method detected proteinuria in 7.5% of patients with COPD, the quantitative method in15%, the protein-creatinine ratio in 20%, the albumin-creatinine ratio – in 22.5%. Significant inverse correlation was found between the severity of airflow obstruction and urinary excretion of β2-microglobulin and albumin.
Conclusion. The most important marker of early renal dysfunction in patients with COPD is the albumin-creatinine ratio. The highest mean levels of albuminuria, protein-creatinine and albumin-creatinine ratios and the marker of tubular dysfunction β2-microglobulin were observed in COPD patients with frequent exacerbations. There was a significant inverse correlation between the severity of airflow obstruction and β2-microglobulin and albuminuria.

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