Features of renal dysfunction in patients with chronic obstructive pulmonary disease


E.V. Bolotova, A.V. Dudnikova

1 Kuban State Medical University of Minzdrav of Russia, Krasnodar; 2 Territorial Clinical Hospital № 2 of Minzdrav of Krasnodar Territory, Krasnodar
Objective. To study features of renal dysfunction and risk factors for CKD in COPD patients.
Materials and methods. 300 inpatient medical records (form 003/y) of the Pulmonary Department of Krasnodar TCH №2 with the verified diagnosis of COPD stages I–IV (76.3% male, mean age 68.51±9.85 years, the average length of the disease 20.9±3.2 years; 23.6% women, mean age 65.95±10,1 years, average length disease 17.2±2.2 years). Estimated glomerular filtration rate (eGFR) was calculated in all patients with the use of the CKD-EPI equation.
Results. Moderate reduction of eGFRCKD-EPI 89‒60 ml/min/1,73m2 (37.3%), hyperfiltration was found in 22% of patients, eGFRCKD-EPI reduction ranged from 59 to 45 ml/min/1,73m2 was detected in 26.7% of patients and eGFRCKD-EPI of 44-30 ml/min/1,73m2 – in 3.3% of patients. There was a high prevalence of potentially modifiable CKD risk factors: elevated CRP levels – in 100% of patients, smoking – in 92%, age 65 years – in 78.6%, hypertension – in 65.6%, genitourinary diseases – in 53 3%, excess BMI and obesity -in 36%, long-term use of NSAIDs – in 36%, impaired carbohydrate metabolism – in 17.6%.
Conclusions. The high prevalence of risk factors for CKD and reduced eGFRCKD-EPI in COPD patients shows that special attention to renal function should be paid in these patients.

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About the Autors


Information about the authors:
Bolotova E.V. – Prof. of Department of Internal Medicine №1 of Faculty of Advanced Training and Professional Retraining of Specialists of KSMU, PhD.
E-mail: bolotowa_e@mail.ru
Dudnikova A.V. – Distance Learning PhD Student of Department of Internal Medicine №1 of Faculty of Advanced Training and Professional Retraining of Specialists of KSMU, Internist, Functional Diagnostic Medicine Practitioner of TCH №2
E-mail: avdudnikova@yandex.ru


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