Membranous glomerulonephritis: a modern view of the problem and treatment options


DOI: https://dx.doi.org/10.18565/nephrology.2020.1.53-60

I.T. Murkamilov, I.S. Sabirov, V.V. Fomin, ZH.A. Murkamilova, K.A. Aytbaev

1) I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan; 2) Kyrgyz Russian Slavic University, Bishkek, Kyrgyzstan; 3) I.M. Sechenov First Moscow State Medical University, Moscow; 4) Research Institute of Molecular Biology and Medicine,Bishkek, Kyrgyzstan
Summary. The review presents the main mechanisms of development and treatment of membranous glomerulonephritis (GLN) with an emphasis on the primary (idiopathic) form. The leading role of anti-PLA2R antibodies in the development of primary membranous GLN has been shown. Some genetic aspects of the occurrence of primary membranous GLN are considered. The development factors and pathogenetic mechanisms of secondary membranous GLN are described. The main provisions in the treatment of the primary form of membranous GLN are considered.
Keywords: membranous glomerulonephritis, B-lymphocytes, monoclonal antibodies, nephrotic syndrome, chronic kidney disease
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About the Autors

Ilkhom T. Murkamilov – PhD in Medical Sciences, Nephrologist, Deputy Associate Professor at the Department of Faculty Therapy, I.K. Akhunbaev Kyrgyz State Medical Academy, Kyrgyz-Russian Slavic University; Bishkek, Kyrgyzstan. E-mail: murkamilov.i@mail.ru. ORCID: org / 0000-0001-8513-9279
Ibragim S. Sabirov – Doctor of Medical Sciences, Professor, Head of the Department of Therapy № 2 in the specialty “General Medicine”, Kyrgyz-Russian Slavic University n.a. the First President of Russia B.N. Yeltsin; Bishkek, Kyrgyzstan. E-mail: sabirov_is@mail.ru. ORCID: 0000-0002-8387-5800
Victor V. Fomin – Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Vice-Rector for Clinical Work and Postgraduate Professional Education, Director of the V.N. Vinogradov Faculty Therapy Clinic, Head of the Faculty Therapy Department № 1, Sechenov First MSMU; Moscow, Russia. E-mail: fomin_vic@mail.ru, ID: 34769949900
Zh.A. Murkamilova – Nephrologist, Correspondence Postgraduate Student at the Department of Therapy № 2 in the specialty “General Medicine”, Kyrgyz-Russian Slavic University n.a. the First President of Russia B.N. Yeltsin; Bishkek; Kyrgyzstan E-mail: murkamilovazh.t@mail.ru. ORCID: org / 0000-0002-7653-0433
Kuvanych A. Aitbaev – Doctor of Medical Sciences, Professor, Head of the Laboratory of Pathological Physiology, Research Institute of Molecular Biology and Medicine; Bishkek, Kyrgyzstan. Email: kaitbaev@yahoo.com


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