Chronic kidney disease in combination with chronic obstructive pulmonary disease under low-mountain conditions: risk factors, early detection and clinical and functional features


D.V. Dolgalev, R.R. Kaliev

International Higher School of Medicine, Department of Internal Diseases; Bishkek, Kyrgyzstan
The concomitant pathology of the renal system often can lead to a mutual burden of various pathology of other organs and systems. Such a proposal requires additional and detailed examination of the urogenital system in patients with chronic obstructive pulmonary disease (COPD). The adequate preventive measures in combination with a more thorough and correct drug therapy in the future will favorably affect the quality of life, and also delay the start of renal replacement therapy.
Purpose. This work is devoted to the analysis of the continuity of risk factors for development, early detection and clinical and functional features of chronic kidney disease (CKD) in patients with COPD under low-mountain conditions (Tokmok, Kyrgyz Republic) at earlier stages of its manifestation.
Material and methods. We examined 82 patients with COPD of varying severity, as well as 10 healthy individuals in low mountains (Tokmok). The mean age of the examined patients was 60.53±15.48 years. At the same time, we analyzed the data of general clinical examination characteristic of each of these nosological units. We also evaluated respiratory function and renal function, including the following parameters: marker of early renal damage, moderately increased albuminuria, glomerular filtration rate, proteinuria, leukocyturia, hematuria, total protein, and serum creatinine levels. Taking into account risk factors for the development of CKD, we determined such parameters as the age of patients, body mass index, smoking index, the main indicator used to calculate the frequency of smoking, as well as anamnestic data on birth weight.
Results. Patients suffering from COPD had risk factors for developing CKD, and they also showed early and significant changes in the renal system, correlating with the degree of bronchial obstruction.
Conclusion Risk factors for the development of CKD detected in the early stages, as well as signs of the pathology of the renal system in patients with COPD, require additional examination, which will serve for a future prevention and further correct nephroprotective therapy at earlier stages.

About the Autors

Dmitry V. Dolgalev – Teaching Assistant at the Department of Internal Diseases, International Higher School of Medicine; Bishkek, Kyrgyzstan. E-mail:
Rysbek R. Kaliev – Doctor of Medical Sciences, Professor at the I.K. Akhunbaev Kyrgyz State Medical Academy; Bishkek, Kyrgyzstan.

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