Русский
Indicators of endogenous intoxication and lipid peroxidation in the dynamics of treatment with α-lipoic acid in men with diabetic nephropathy at the stage of microalbuminuria
DOI: https://dx.doi.org/10.18565/nephrology.2021.3.38-43
M.A. Darenskaya, E.V. Chugunova, S.I. Kolesnikov, L.A. Grebenkina, N.V. Semenova, O.A. Nikitina, L.I. Kolesnikova
Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia
Objective. Assessment of the indices of endogenous intoxication and lipid peroxidation products in men with type 1 diabetes mellitus (DM1) with microalbuminuria in the dynamics of treatment with α-lipoic acid.
Material and methods. The study was carried out with the participation of 28 men of reproductive age with DM1 and microalbuminuria in the dynamics of treatment with α-lipoic acid. The control group consisted of 28 healthy men. The comparison group consisted of 18 men of the same age with DM1 and normoalbuminuria. The content of medium molecular weight peptides (MMWP), absorbing at 238, 254, 280 nm, as well as the concentration of primary, secondary and end products of lipid peroxidation were estimated. Spectrophotometry and fluorometry methods were used.
Results. The results of the examination of men with DM1 and microalbuminuria compared to the control showed an increase in the levels of MMWP-238, -280, as well as lipid peroxidation products - diene conjugates (DC), ketodienes and conjugated trienes, TBA-reactive substances (TBARS) and Schiff bases (SB); compared to the comparison group - increased values of MMWP-280, TBARS and SB. After the treatment with α-lipoic acid, there was a decrease in the levels of MMWP-280, DC, TBARS and SB.
Conclusion. The data obtained demonstrate the presence of metabolic manifestations of endogenous intoxication and activation of lipid peroxidation processes at different stages in patients with DM1 and microalbuminuria. The treatment with α-lipoic acid contributed to the relative normalization of these parameters. The need to control and correct these indicators in male patients with DM1 and early manifestations of diabetic nephropathy should be an important component of pathogenetic treatment and prevention of complications.
About the Autors
Marina A. Darenskaya – Dr. Sci. (Biol.), Leading Researcher, Laboratory of Pathophysiology, Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel .: 8 (964) 227-52-72; e-mail: marina_darenskaya@inbox.ru. ORCID: https://orcid.org/0000-0003-3255-2013.
Elena V. Chugunova – Postgraduate Student at the Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel.: +7 (3952) 20-73-67.
ORCID: https://orcid.org/0000-0002-2546-6320.
Sergey I. Kolesnikov – Member of the Russian Academy of Sciences, Chief Researcher, Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel .: +7 (3952) 20-73-67. ORCID: https://orcid.org/0000-0003-2124-6328.
Lyudmila A. Grebenkina – Dr. Sci. (Biol.), Chief Researcher, Laboratory of Pathophysiology, Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel .: +7 (3952) 20-73-67. ORCID: https://orcid.org/0000-0002-1263-5527.
Natalya V. Semenova – Dr. Sci. (Biol.), Leading Researcher, Laboratory of Pathophysiology, Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel.: +7 (3952) 20-73-67. ORCID: https://orcid.org/0000-0002-6512-1335.
Olga A. Nikitina – Cand. Sci. (Biol.), Junior Researcher, Laboratory of Pathophysiology, Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel .:
+7 (3952) 20-73-67. ORCID: https://orcid.org/0000-0003-1926-9694.
Lyubov I. Kolesnikova – Member of the Russian Academy of Sciences, Scientific Director of the Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, tel .: +7 (3952) 20-73-67. ORCID: https://orcid.org/0000-0003-3354-2992.
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