Русский
Intestinal fatty acid binding protein as biomarker of enterocyte injury in patients with renal failure
DOI: https://dx.doi.org/10.18565/nephrology.2023.3.37-41
Pyatchenkov M.O., Sherbakov E.V., Trandidna A.E., Belskykh A.N.
Military Medical Academy, Saint Petersburg, Russia
Material and methods. The cross-sectional study included 3 groups of patients: 1) 20 relatively healthy individuals with GFR>60 ml/min/1.73 m2; 2) 30 patients with CKD C3a-5 (GFR<60 ml/min/1.73 m2); 3) 38 patients with end-stage renal disease (ESRD) receiving hemodialysis treatment. All participants had no clinical manifestations of intestinal pathology. The concentration of I-FABP in blood serum was assessed by ELISA using commercially available kit.
Results. I-FABP levels significantly increased in parallel with an advance of renal insufficiency and reached maximum values in patients with ESRD: 1719,5 (1279,8–1979,6), 3533,2 (2449,5–4234,1), 6340,7 (5436–6732,3) pg/ml respectively. In subjects at the predialysis stages of CKD, a strong inverse correlation of I-FABP with GFR was found (R=0,946, p<0.001).
Conclusion. A decrease in GFR leads to a significant increase of serum I-FABP levels in patients with impaired renal function. This should be taken into account when using I-FABP as a biomarker of enterocytes injury in patients with renal failure.
About the Autors
Pyatchenkov Mikhail Olegovich – candidate of medical Sciences, senior lecturer of Department of nephrology and blood purification, Military Medical Academy of the Ministry of Defense of the Russian Federation. Address: 194044 Saint Petersburg, 6 Akademika Lebedeva str.; e-mail: pyatchenkovMD@yandex.ru. ORCID: 0000-0002-5893-3191; SPIN-code: 5572-8891.
Sherbakov Evgeniy Viacheslavovich – nephrologist in the Military Medical Academy of the Ministry of Defense of the Russian Federation. Address: 194044 Saint Petersburg, 6 Akademika Lebedeva str.; e-mail: evgenvmeda@mail.ru. ORCID: 0000-0002-3045-1721; SPIN-code: 6337-6039.
Trandina Aleksandra Evgenievna – doctor of clinical laboratory diagnostics Research department (Biomedical Research) of the RC, Military Medical Academy of the Ministry of Defense of the Russian Federation. Address: 194044 Saint Petersburg, 6 Akademika Lebedeva str.; e-mail: sasha-trandina@rambler.ru. ORCID: 0000-0003-1875-1059; SPIN- code: 6089-3495.
Belskykh Andrei Nikolaevich – doctor of medical Sciences, Professor, Corresponding Member, Russian Academy of Sciences, Head of Department of nephrology and blood purification, Military Medical Academy of the Ministry of Defense of the Russian Federation. Address: 194044 Saint Petersburg, 6 Akademika Lebedeva str.; e-mail: d0c62@mail. ru. Author ID: 273050, ORCID:0000-0002-0421-3797
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