Русский
Prognostic value of the Charlson comorbidity index i n patients aged 60 years and older starting chronic dialysis treatment
DOI: https://dx.doi.org/10.18565/nephrology.2024.1.30-36
Kurylovich K.A., Komissarov K.S., Krasko O.V.
1) Institute for Advanced Training and Retraining of Healthcare Personnel, Belarusian State Medical University, Minsk, Republic of Belarus; 2) 1st City Clinical Hospital, Minsk, Republic of Belarus; 3) Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology, Minsk, Republic of Belarus; 4) United Institute of Informatics Problems of the National Academy of Sciences of Belarus, Minsk, Republic of Belarus
Material and methods. Analysis of data from 246 patients ≥60 years old with stage 5 CKD.
Results. A univariate analysis was performed, predictors of fatal outcome: age ≤65 years, CCI >5 points, diuresis ≤350 ml/day, presence of hyperhydration, predialysis creatinine levels (pdCr) ≤514 µmol/l, predialysis urea levels (pdU) >44 mmol/l, glomerular filtration rate (GFR) according to the CKD-EPI formula ≤3.1 ml/min/1.73 m2. Multivariate analysis, predictors of fatal outcome: age >65 years (hazard ratio - HR=1.7, 95% confidence interval - CI 1.1–2.4), CCI >5 points (HR=3, 95% CI 2–4, 4), pdCr ≤514 µmol/l (HR=2.7, 95% CI 1.7–4.5) and pdU >44 mmol/l (HR=1.8, 95% CI 1.2–2, 9).
Conclusion. CCI can be used when choosing treatment tactics for patients aged ≥60 years with stage 5 CKD along with other generally accepted predictors of fatal outcome (pdCr, pdU, age).
About the Autors
Kristina A. Kurylovich – Postgraduate Student at the Department of Urology and Nephrology, Institute of Advanced Training and Retraining of Healthcare Personnel, Belarusian State Medical University. Address: Bldg. 3, 3 P. Brovka st., Minsk, 220013 st.; Nephrologist, Hemodialysis Department, 1st City Clinical Hospital.
Address: 64 Independence Ave., Minsk, 220013; tel.: +(375 44) 740-32-95; e-mail: khruns89@gmail.com. ORCID: https://orcid.org/0000-0002-9112-4863.
Kirill S. Komissarov – Cand.Sci. (Med.), Associate Professor, Head of the Department of Nephrology, Renal Replacement Therapy and Kidney Transplantation, Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology. Address: 8 Semashko st., Minsk, 220087; tel. +(37517) 277-20-35, +(375 29) 680-70-97;
e-mail: kirill_ka@tut.by. ORCID: http://orcid.org/0000-0002-2648-0642.
Olga V. Krasko – Cand. Sci. (Tech), Leading Researcher at the Laboratory of Bioinformatics, United Institute of Informatics Problems of the National Academy of Sciences of Belarus. Address: 6 Surganov st., Minsk, 220012; tel.: +(375 29) 707-88-03; e-mail: krasko@newman/bas-net.by. ORCID: https://orcid.org/0000-0002-4150-282X.
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