Patients with arterial hypertension, who had undergone ischemic stroke, were treated with fixed combination of eprosartan and hydrochlorothiazide. Ambulatory blood pressure monitoring was performed and cognitive function was evalusated by MMSE scale. All patients were stratified into 3 groups, according to the estimated glomerular filtration rate (eGFR) level: 1st – eGFR >90 ml/min/1,73m2, 2nd – 50 – 89 ml/min/1,73m2, 3rd – 30 – 59 ml/min/1,73m2. MMSE scale changed after eprosartan and hydrochlorothiazide treatment maximally in group 1, in group 3 changes were minimal. Conclusion. Cognitive dysfunction is most prominent in patients with arterial hypertension, associated with iashemic stroke, who has low eGFR.

Keywords: glomerular filtration rate, arterial hypertension, ischemic stroke