Steroid-resistant nephritic syndrome in childhood: single-centre experience

S.P. Fomina, I.V. Bagdasarova, T. Pavlenko

Aim. Determination of prevalence of chronic kidney disease (CKD) and it's risk factors in patients with chronic heart failure (CHF). Methods. 167 patients (21 male and 146 female, mean age 60,9±11,4 years) with CHF I-IV (NYHA) were included into the study. Risk factors - body mass index (BMI), serum total cholesterol (TC), low density (LDL-C) and high density lipoprotein (HDL-C) cholesterol, triglycerides (TG), uric acid and creatinine level - were determined. Blood pressure (BP) and heart rate (HR) were determined. Glomerular filtration rate (GFR) was assessed by Cockroft-Gault formula. Results. According to age increase CHF becomes more severe and is associated with GFR fall with simultaneous creatininemia increase. Increase of CHF severity is accompanied with BMI and GFR decrease, as well as with the increase in HR. Higher mean BP is associated with higher creatininemia, low diastolic BP - with decrease in GFR. Rise in serum uric acid level correlates with dislipidemia. Conclusion. In CHF patients CKD development and progression is associated with risk factor dynamics.

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