Specific adipokines in children with steroid-resistant nephrotic syndrome
E.V. Kulina, I.M. Osmanov, E.S. Vozdvijenskaya
Aim. Assessment of role of adipokines (leptin, adiponectin) in kidney damage in steroid-resistant nephrotic syndrome (SRNS) in children. Methods. 16 and 18 girls (mean age 12,69±4,21 years) with SRNS were included into the study. Longevity of the disease was 4,61±4,61 years in the study group, 4,04±3,04 years in the control group. Groups of patients did not differ significantly according to the main clinical and laboratory parameters. In all patients plasma concentrations of leptin and adiponectin were determined. Results. In active SRNS elevation of plasma adiponectin level was found in comparison with children, who had remission of nephrotic syndrome (median 22,1 mg/ml and 14,7 mg/ml, p=0,01). Positive correlation between adiponectinemia and total cholesterol (r =0,601, p<0,05), low density lipoprotein cholesterol (r = 0,855, p<0,05) were found. Adiponectinemia negatively correlated with serum protein level (r=- 0,689, p<0,05), serum albumin level (r=- 0, 642, p<0,05) and age (r =-0,666, p<0,05). Leptin/adiponectin ratio in children with SRNS was sighnificantly higher, than in SRNS remission (0,64 vs 0,35, p<0,05). Conclusion. In children with SRNS production of adipokines increases in active renal disease.
Keyword: adiponectin, children, cardiovascular risk, steroid-resistant nephrotic syndrome