The role of leptin in the pathogenesis of malnutrition in chronic hemodialysis patients


A.A. Jakovenko, A.M. Esajan, A.Sh. Rumjancev, V.M. Somova

Aim. To clarify the role of leptin in the development of malnutrition in chronic hemodialysis (HD) patients.
Material and methods. The study sample consisted of 78 patients with end-stage renal disease treated with chronic HD, including 38 women and 40 men aged 52,2±12,9 year. Nutritional status and body composition were assessed by integrated nutritional evaluation, caliper measurements, and bioimpedance analysis. The concentration of plasma leptin was determined by radioimmunoassay (Active Human Leptin Elisa, 10-23100i, DSL, USA). The reference ranges were for women – 1,1–27,5 for men – 0,5–13,8 ng/ml.
Results. The study results showed a significant reduction of the basic indicators of nutritional status in HD patients with hyperleptinemia.
Conclusion. Hyperleptinemia may be an independent factor causing the development of malnutrition in chronic HD patients.

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