The kidney as a target organ of hypertension among residents of Mountain Shoria


T.A. Mulerova, E.S. Filimonov, M.Yu. Ogarkov, N.N. Epifantseva, V.N. Vyalova, L.G. Kheringson, N.A. Troshkina, A.V. Kolbasko

Aim. To determine the relationship between the main cardiovascular risk factors and elevated levels of albuminuria and estimated glomerular filtration rate (eGFR) in patients with arterial hypertension (AH) among indigenous and non-indigenous residents of Mountain Shoria.
Material and methods. The study comprised 465 non-indigenous adults living in Mountain Shoria, of which 214 had hypertension, and 721 indigenous nationals, of which 288 had hypertension, matched by sex and age. Initial examination included the lipid profile, anthropometric data, the level of urine albumin and eGFR. Statistical analysis was conducted using variation statistics.
Results. Non-indigenous people were more likely to have hypertension: 46.1% versus 39.9% in Shorians on account of the male population. The incidence of high-level albuminuria in patients with hypertension did not differ significantly and amounted to 23.4% of Shorians and 23.7% among non-indigenous ethnic group. The risk of developing high-level albuminuria in hypertensive patients in Shorians was associated with the severity and duration of the disease, age, hypertriglyceridemia and decreased HDL cholesterol, while in the group of non-indigenous residents with age and obesity, including abdominal. In hypertensive indigenous nationals there was the relationship between decreased eGFR of less than 90 mL/min/1.73m2, duration of hypertension, age, overweight and obesity, smoking and elevated blood triglyceride levels. In non-indigenous participants decreased eGFR was associated only with age and AH grade.
Conclusion. These findings allow predicting renal dysfunction among the hypertensive population living in Mountain Shoria.

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