Objective. Evaluation of the clinical and laboratory features of erythrocyte indices and structural restructuring of the left ventricular myocardium in patients with chronic glomerulonephritis depending on gender differences.
Material and methods. A total of 305 patients with chronic glomerulonephritis (CGN) at the pre-dialysis stage of chronic kidney disease (CKD) were included in the study, there were 206 men (Group 1) and 99 women (Group 2). All patients underwent general clinical and echocardiographic examinations.
Results. Patients of group 1 (men) had higher diastolic blood pressure (P=0.004), indexed left ventricular (LV) myocardial mass (P=0.005), LV hypertrophy (P=0.005), and concentric left ventricular hypertrophy (P = 0.005) compared with patients of group 2 (women). At the same time, the double product index was significantly higher in the group of women (P=0.027). A significant decrease in the hemoglobin level (P=0.005), hematocrit (P=0.005), the number of erythrocytes (P=0.005), platelets (P=0.045) and a decrease in the diameter of erythrocytes (P=0.005) were detected in the group of women. At the same time, in this group, there was a noticeable slowdown in the glomerular filtration rate (GFR) (P=0.005) and a decrease in the relative urine density (P=0.005). A close relationship between the diameter of erythrocytes and the GFR value in both men and women was found. In the general group, a negative relationship between the erythrocyte diameter and the double product index was recorded (r= -0.156; P=0.016). Both in the group of men and women, a decrease in the erythrocyte diameter was accompanied by an increase in LVMMI (r= -0.167; P=0.033 and r = -0.264; P=0.020, respectively).
Conclusion. A decrease in the erythrocyte diameter, a decrease in the hemoglobin level in female patients with chronic glomerulonephritis were accompanied by a significant slowdown in GFR and an increase in cardiovascular risk (myocardial oxygen demand), and in the group of male patients – with the development of a concentric remodeling and concentric left ventricle hypertrophy, an increase in the plasma uric acid level.

Keywords: erythrocyte indices, glomerular filtration rate, chronic glomerulonephritis, left ventricular hypertrophy