Evaluation of humoral response to Gam-Covid-Vac (Sputnik V) vaccination against COVID-19 in patients on hemodialysis and peritoneal dialysis
Shutov E.V., Bolshakov S.A., Kotlyarova G.V., Emelyanova E.B., Sorokoletov S.M., Dolidze D.D.
1) BOTKIN HOSPITAL, MOSCOw, RUSSIA;
2) RUSSIAN MedICAL ACAdemy Of CONTINUING PROfeSSIONAL EdUCATION, MOSCOw, RUSSIA
Background. New Coronavirus infection (COVID-19) is a highly contagious infectious disease causing 20 to 30% death in patients with chronic kidney disease receiving hemodialysis or peritoneal dialysis. Vaccination as one of the most effective methods of reducing mortality has been given the main place in disease prevention.
Objective: Evaluation of the level of humoral response to Gam-Covid-Vac (Sputnik V) vaccination against COVID-19 in patients receiving hemodialysis and peritoneal dialysis compared with healthy individuals.
Material and methods. The study included 103 dialysis patients, of whom 48 were uninfected before standard vaccination and 55 patients after a new coronavirus infection; 25 and 30 healthy volunteers served as controls, respectively. Humoral response to vaccination was assessed in all subjects by total SARS-CoV-2 IgG and IgG antibody levels to the receptor-binding domain of the S1 subunit of the SARS-CoV-2 protein. Seroconversion levels were compared in all groups (patients on hemodialysis, peritoneal dialysis and controls).
Results. Levels of SARS-CoV-2 IgG were: in hemodialysis patients 10.2±2.2 U/ml, peritoneal dialysis patients 9.3±2.9 U/ml and they did not differ statistically significantly between the groups. In the control group, it was significantly higher: 17.37±5.5 U/ml (p<0.05), compared to dialysis patients. IgG level of antibodies to spike (S) protein of coronavirus was 79,9±12,7 BAU/ml in patients on hemodialysis, 80,7±17,5 BAU/ml on peritoneal dialysis. In the control group it was significantly higher: 272,5±17,6 BAU/ml (p<0,05). The study of the antibody levels after vaccination in the groups of COVID-19 convalescent showed no significant differences between the groups.
Conclusions. Patients who had not previously infection of COVID-19 and received peritoneal dialysis and hemodialysis had a reduced humoral response to Gam-Covid-Vac (Sputnik V) vaccination compared to controls. This necessitates dynamic monitoring of antibody levels and earlier administration of a booster dose of the vaccine. Patients on dialysis and controls who underwent COVID-19 had comparable levels of seroconversion after vaccination.
About the Autors
Evgeny V. Shutov – MD, PhD, Head of the Interdistrict Nephrology Center, Botkin Hospital, Head of the Department of Nephrology and Dialysis, Russian Medical Academy of Continuing Professional Education Moscow; e-mail: email@example.com. ORCID: https://orcid.org/0000-0002-1047-0378.
Stepan A. Bolshakov – therapist, junior researcher of the department of science of Botkin Hospital, Moscow; e-mail: firstname.lastname@example.org. ORCID: https://orcid.org/0000-0002-4556-6740.
Galina V. Kotlyarova – Head of the hemodialysis department of the interdistrict nephrological center of Botkin Hospital, Moscow; e-mail: email@example.com. ORCID: https:// orcid.org/0000-0001-9970-4486.
Elvira B. Emelyanova – MD, Head of the clinical diagnostic laboratory of Botkin Hospital, Moscow; e-mail: firstname.lastname@example.org.
Sergey M. Sorokoletov – MD, PhD, deputy chief physician for therapeutic care of Botkin Hospital, Moscow; e-mail: email@example.com.
David D. Dolidze – MD, PhD, Head of scientific-clinical department, Botkin Hospital, Moscow; e-mail: firstname.lastname@example.org. ORCID: https://orcid.org/0000-0002-0517-8540