Русский
Right ventricle, pulmonary pressure and their relationship with renal function in patients with overweight and obesity
DOI: https://dx.doi.org/10.18565/nephrology.2025.1.22-28
Murkamilov I.T., Aitbaev K.A., Fomin V.V., Yusupov F.A., Yusupova T.F., Yusupova Z.F., Duysheeva G.K., Khakimov Sh.Sh., Abdurakhmanov I.U., Solizhonov Zh.I., Ymankulov D.S., Khabibullaev K.K.
1) I.K. Akhunbaev Kyrgyz State Medical Academy named after, Bishkek, Kyrgyzstan; 2) Salymbekov University, Bishkek, Kyrgyzstan; 3) Research Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan; 4) Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 5) Osh State University, Osh, Kyrgyzstan; 6) Saint Petersburg State University, Saint Petersburg, Russia; 7) Kazan State Medical University, Kazan, Russia; 8) Medical Center "Green Clinic", Bishkek, Kyrgyzstan
Objective. Analysis of the relationship between the right ventricle (RV) function, pulmonary pressure and the state of the kidneys in patients with overweight and obesity.
Material and methods. An analysis of clinical, laboratory and echocardiographic data of 305 patients with overweight (n=155) and obesity (n=150), whose mean age was 54.7±11.7 years, was performed. Patients with functional class III–IV chronic heart failure, fever, Lower extremity varicose vein disease, a history of thromboembolic complications, type 1 diabetes mellitus (DM1), liver cirrhosis, nephrotic syndrome, patients on renal replacement therapy, and residents of high-mountain areas were excluded from the study.
Results. Compared with overweight patients, obese patients were more likely to have arterial hypertension (58.0%), DM2 (22.0%) and comorbid diseases (31.3%). This group also had higher diastolic blood pressure (89±11 mmHg vs. 86±11 mmHg; p<0.05), venous blood glucose levels (7.00±3.16 mmol/l vs. 5.76±2.25 mmol/l; p<0.05), triglycerides: 1.66 [1.13; 2.26] mmol/l vs. 1.36 [0.95; 2.25] mmol/l (p<0.05), C-reactive protein – 3.2 [1.6; 7.9] mg/l vs. 2.0 [0.6; 5.3] mg/L (p<0.05), RV size – 2.23±0.40 cm versus 2.09±0.31 cm (p<0.05), pulmonary artery diameter – 2.37±0.38 cm versus 2.24±0.25 cm (p<0.05) and pulmonary systolic pressure – 32.7±12.3 mmHg versus 29.4±6.76 mmHg (p<0.05). Serum calcium level was lower (2.10±0.41 mmol/L versus 2.21±0.24 mmol/L; p<0.05). A direct correlation was established between RV wall thickness and proteinuria (r=0.342; p<0.05); cystatin C and the size of the right ventricle (r=0.190; p=0.002), its wall thickness (r=0.145; p=0.019), the diameter of the pulmonary artery (r=0.318; p=0.005), and the level of systolic pulmonary pressure (r=0.264; p=0.005). An inverse correlation was recorded between the estimated glomerular filtration rate (eGFR) and the size of the right ventricle (r=-0.254; p=0.005), its wall thickness (r=-0.184; p=0.003), the diameter of the pulmonary artery (r=-0.341; p=0.005), and the level of systolic pulmonary pressure (r=-0.285; p=0.005).
Conclusion. In patients with overweight and obesity, significant relationships were found between the parameters of the right ventricle and pulmonary pressure with the kidney filtration function (cystatin C, GFR).
About the Autors
Ilkhom T. Murkamilov – Dr.Sci. (Med.), Associate Professor at the Department of Faculty Therapy, I.K. Akhunbaev KSMA, Director of the Multidisciplinary Medical Center "Doc University Clinic", Salymbekov University. Address: 92 Akhunbaev str., Bishkek, 720020; tel.: (+996) 557-221-983; e-mail: murkamilov.i@mail.ru.
ORCID: https://orcid.org/0000-0001-8513-9279.
Kubanych A. Aitbaev – Dr.Sci. (Med.), Professor, Head of the Department of Pathological Physiology, Research Institute of Molecular Biology and Medicine.
Address: 3 T. Moldo str., Bishkek, 720040; tel.: (+996) 555-758-476; e-mail: aitbaev.kuban1940@gmail.com. ORCID: https://orcid.org/0000-0003-4973-039X.
Viktor V. Fomin – Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Therapy No. 1, N.V. Sklifosovsky Institute of Clinical Medicine, Vice-Rector for Innovation and Clinical Activities, Sechenov First Moscow State Medical University. Address: 2 Bolshaya Pirogovskaya St.,
Moscow, 119991; tel.: 8 (495) 609-14-00, ext. 2142; e-mail: fomin_vic@mail.ru. ORCID: https://orcid.org/0000-0002-2682-4417.
Furkat A. Yusupov – Dr.Sci. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University.
Address: 331 Lenin St., Osh, 723500; Tel.: (+996) 990-999-291; E-mail: furcat_y@mail.ru. ORCID: https://orcid.org/0000-0003-0632-6653.
Tursunoy F. Yusupova – Clinical Resident of the Department of Neurology, Neurosurgery and Psychiatry, Medical Faculty, Osh State University.
Address: 331 Lenin St., Osh, 723500; tel.: (+996) 707-130-938; e-mail: yusupova_tursunoy_f@mail.ru. ORCID: https://orcid.org/0000-0002-8502-2203.
Zulkhumor F. Yusupova – 4th year student at the Medical Faculty, Osh State University. Address: 331 Lenin St., Osh, 723500; tel.: (+996) 707-130-938;
e-mail: zulkhumor.yusupova.f_05@mail.ru. ORCID: https://orcid.org/0000-0001-7621-1128.
Gulzat K. Duysheeva – Teaching Assistant at the Department of Faculty Therapy, I.K. Akhunbaev KSMA. Address: 92 Akhunbaev str., Bishkek, 720020;
tel.: (+996) 770-252-528; e-mail: guzyu_88@mail.ru.
Shavkat Sh. Khakimov – Head of the Department of Intensive Care Medicine, Therapy and Diagnostics, Salymbekov University. Address: 144 Bokonbaev str., Bishkek, 720040; tel.: (+996) 551-660-013; e-mail: hakimovshaki13@gmail.com. ORCID: https://orcid.org/0009-0004-0437-0188.
Islombek U. Abdurakhmanov – Therapist, Researcher, City Polyclinic No.120, Address: 7–9 Universitetskaya emb., St. Petersburg, 199034; Tel.: (7952) 2275047;
E-mail: ali_islam95@mail.ru. ORCID: https://orcid.org/0009-0006-0660-0113.
Zhaloliddin I. Solizhonov – 6th-year student of the Faculty of Medicine, Kazan State Medical University. Address: 49 Butlerova st., Kazan, 420012; Tel.: (+495) 967-4690-0438; E-mail: jaloliddinsolijonov44@gmail.com. ORCID: https://orcid.org/0009-0003-0078-0609.
Daniyar S. Ymankulov – Doctor-Researcher, Plastic Surgeon, Green Clinic. Address: 118 Isanov st., Bishkek, 720040; tel.: (+996) 551-196-991;
e-mail: ymankulov9595@mail.ru. ORCID: https://orcid.org/0009-0000-4975-1196.
Komil K.Khabibullaev – 6th year student of the Faculty of Medicine, I.K. Akhunbaev KSMA. Address: 92 Akhunbaev st., Bishkek, 720020; Tel.: (+996) 706-474-201,
e-mail: khabibullaevkomil2001@gmail.com. ORCID: https://orcid.org/0009-0004-5508-8019.
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