Тубулоинтерстициальный аппарат почки и его поражение при артериальной гипертензии


Г.П. Арутюнов, Л.Г. Оганезова

ГОУ ВПО РГМУ Росздрава, Москва
Обсуждаются клиническое, патогенетическое прогностическое значения поражения почечного тубулоинтерстиция при артериальной гипертензии.

Литература


1. Klag M.J., Whelton P.K., Randall B.L. et al. Blood pressure and end-stage renal disease in men. N Engl J Med 1996;334(1):13–18.
2. Sarnak M.J., Levey A..S., Schoolwerth A.C. et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003;108:2154–2169.
3. Dries D.L., Exner D.V., Domanski M.J. et al. The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction. J Am Coll Cardiol 2000;35:681–689.
4. Mahan N.G., Blackstone E.H., Francis G.S. et al. The prognostic value of estimated creatinine clearance alongside functional capacity in patients with chronic congestive heart failure. J Am Coll Cardiol 2002;40:1106–1113.
5. Hillege H.L., Girbes A.R., de Kam P.J. et al. Renal function, neurohormonal activation, and survival in patients with chronic heart failure. Circulation 2000;102:203–10.
6. Eknoyan G: Chronic tubulointerstitial nephropathies. In: Schrier R.W., Gottschalk CW (eds.) Diseases of the Kidney (edn. 6). Boston: Little Brown 1997:1983–2015.
7. Lemley K.V., Kriz W. Anatomy of the renal interstitium. Kidney Int 1991;39:370–381.
8. Bohman S. The ultrastructure of the renal interstitium. Contemp Issues Nephrol 1983;10:1–34.
9. Pedersen J.C., Persson A.E.G., Maunsbach A.B. Ultrastructure and quantitative characterization of the cortical interstitium in the rat kidney. In: Maunsbach AB, Olsen TS, Christensen EL (eds.) Functional Ultrastructure of the Kidney. London, Academic Press, 1980;443–457.
10. Kus W., Napiwotzky P. Structural and functional aspects of the renal interstitium. Contr Nephrol 1979;16:104–108.
11. Swann H.G., Norman R.J. The periarterial spaces of the kidney. Texas Rep Biol Med 1970;28:317–34.
12. Kriz W, Lehir M. Pathways to nephron loss starting from glomerular diseases—Insights from animal models. Kidney Int 2005;67:404–419.
13. Kriz W. A periarterial pathway for intrarenal distribution of renin. Kidney Int 1987;31:51–56.
14. Eknoyan G., McDonald M.A., Appel D., Truong L.D. Chronic tubulointerstitial nephritis: correlation between structural and functional findings. Kidney Int 1990;38:736–743.
15. Tylicki L., Manitius J., Lysiak-Szydlowskaw, Rutkowski B. Tubular injury: The first symptom of hypertensive kidney involvement? Med Sci Monit 2003;9:CR135–CR41.
16. Johnson R.J., Herrera-Acosta J., Schreiner G., Rodriguez-Iturbe B. Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N Engl J Med 2002;346:913–923.
17. Thomas S.E., Anderson S., Gordon K.L. et al. Tubulointerstitial disease in aging: evidence for underlying peritubular capillary damage, a potential role for renal ischemia. J Am Soc Nephrol 1998;9(2):231–242.
18. Matsumoto M., Tanaka T., Yamamoto T. et al. Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis. J Am Soc Nephrol 2004;15:1574–1581.
19. Mazzali M., Jefferson J.A. Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertension. Kidney Int 2003;63:2088–93.
20. Mai M., Geiger H., Hilgers K.F. et al. Early Interstitial Changes in Hypertension-Induced Renal Injury, Hypertension. 1993;2:754–765.
21. Eknoyan G., Truong L.D. Atlas Of Diseases Of The Kidney, On-Line Edition By ISN Informatics Commission And NKF Cybernephrology. Ch. 6, Renal Interstitium And Major Features Of Chronic Tubulointerstitial Nephritis.
22. Kuncto G.S., Neilson E.G., Haverty T. Mechanisms of tubulointerstitial fibrosis. Kidney Int 1990;39:550–556.
23. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanisms and therapeutic intervention. J Am Soc Nephrol 2004;25:1–12.
24. Boor P., Sebekovaґ K. Treatment targets in renal fibrosis Nephrol Dial Transplant 2007;22:3391–407.
25. Bapat S., Post J., Braam B. et al. Visualizing tubular lipid peroxidation in intact renal tissue in hypertensive rats. J Am Soc Nephrol 2002;12:2990–2996.
26. Risdon R.A., Sloper J.C., De Wardener H.E. Relationship between renal function and histological changes found in renal biopsy specimens from patients with persistent glomerular nephritis. Lancet 1968;2:363–366.
27. Rodriguez-Iturbe B., Johnson R.J., Herrera-Acosta J. Tubulointerstitial damage and progression of renal failure, Kidney Int 2005;68(9):S82–S86.


Об авторах / Для корреспонденции


Арутюнов Г.П. – профессор, заведующий кафедрой терапии московского факультета ГОУ ВПО РГМУ, проректор по научной и лечебной работе ГОУ ВПО РГМУ Росздрава, д.м.н.;
Оганезова Л.Г. – ассистент кафедры терапии московского факультета ГОУ ВПО РГМУ Росздрава, к.м.н.
E-mail: lianaogan@gmail.com


Похожие статьи


Бионика Медиа