Clinical sighnificance of adiponectinemia in development of target organ-damage in metabolic syndrome, associated with non-alcoholic fatty liver disease


E.A. Saginova, M.M. Severova, M.G. Galliamov, N.V. Ermakov, A.V. Rodina, V.V. Fomin, N.A. Moukhin

Aim. Assessment of clinical significance of plasma adiponectin level in development of target organ damage (TOD) in metabolic syndrome, associated with non-alcoholic fatty liver disease.
Methods. 86 patients (64 male, 22 female; mean age 44+11 years) with metabolic syndrome, associated with non-alcoholic fatty liver disease (ultrasound features of hepatic stetatosis and/or non-alcoholic steatohepatitis) were included into the study. Risk factors and plasma levels of leptin and adiponectin were determined.
Results. Frequency of left ventricular hypertrophy, carotid atherosclerosis and chronic kidney disease increaser significantly according to the elevation of number of signs of target organ damage. Patients with >3 signs of target organ damage had the highest rate of non-alcoholic steatohepatitis (78% vs 39% in patients with 1 sign of TOD, р<0,05). Increase in number of signs of TOD was associated with elevation of leptin/adiponectin ratio. Plasma level of adiponectin significantly decreased in patients with carotid atherosclerosis (14,9±10,8 vs 32,5±22,5 mcg/ml, р=0,005) and inversely correlated with intima-media thickness of common carotid artery. Plasma adiponectin level directle correlated with HDL plasma level, leptinemia and DeRitis ratio.
Conslusion. In metabolic syndrome, associated with non-alcoholic fatty liver disease, organoprotective effects of adiponectin gradually diminish, that leads to increase of intensity of TOD.

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