Significance of acyl-ghrelin in the development of nutritional deficiency in patients with end-stage renal failure treated with programmed hemodialysis


A.A. Yakovenko, A.Sh. Rumyantsev, A.G. Kucher, Yu.Yu. Asanina

1 FPGE First St. Petersburg State Medical University n.a. Acad. I.P. Pavlov; 2 Polyclinic № 15, St. Petersburg
Aim. Identification of relationship between serum concentration of acyl-ghrelin and main indicators of nutritional deficiency in patients on chronic HD.
Materials and methods. A total of 102 patients with end-stage renal failure treated by chronic hemodialysis, including 52 men and 50 women aged 49±7.7 years, were evaluated. All patients underwent fibrogastroduodenoscopy with biopsy of antrum and body of the stomach and the definition of Helicobacter pylori infection. Nutritional status and component composition of the patient’s body were assessed by a comprehensive nutritional assessment, kaliperometry, and bioimpedancemetry. Evaluation of serum acyl-ghrelin was carried out by the method of enzyme-linked immunosorbent assay (ELISA) using commercially available kits (Spi-bio, Montignyle Bretonneux, France).
Results. The study has demonstrated a significant decrease in the serum acyl-ghrelin level with an increase in the severity of atrophic changes in the mucous membranes of different parts of the stomach, as well as the dissemination of gastric mucosa by Helicobacter pylori. There was a significant positive relationship between the serum acyl-ghrelin level and main indicators of nutritional status of patients.
Conclusion. Reduction of serum acyl-ghrelin level may be considered as one of the factors contributing to the development of nutritional deficiency in patients treated by chronic hemodialysis.

About the Autors


Information about the authors:
Yakovenko A.A. - Associate Professor at the Department of Nephrology and Dialysis FPGE First St. Petersburg State Medical University n.a. Acad. I.P. Pavlov
E-mail: leptin-rulit@mail.ru
Rumyantsev A.Sh. – Professor at the Department of Propaedeutics of Internal Diseases FPGE First St. Petersburg State Medical University n.a. Acad. I.P. Pavlov
Kucher A.G. - Professor at the Department of Propaedeutics of Internal Diseases FPGE First St. Petersburg State Medical University n.a. Acad. I.P. Pavlov
Asanina Yu.Yu. - Head of the of gastroenterological unit at the polyclinic № 15, St. Petersburg.


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